ANALYSIS OF CARBOHYDRATES AND GLYCOCONJUGATES BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY: AN UPDATE FOR 2011-2012

被引：28

作者：

Harvey, David J. ^{[1
]}

机构：

[1] Univ Oxford, Oxford Glycobiol Inst, Dept Biochem, Oxford OX1 3QU, England

来源：

MASS SPECTROMETRY REVIEWS | 2017年 / 36卷 / 03期

关键词：

MALDI; carbohydrates; glycoproteins; glycolipids; biopharmaceuticals; MALDI-TOF-MS; HUMAN SERUM-ALBUMIN; N-LINKED GLYCANS; CELL-WALL POLYSACCHARIDES; DESORPTION-IONIZATION-TIME; SOLID-PHASE SYNTHESIS; IN-SOURCE DECAY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; RETICULUM-ASSOCIATED DEGRADATION; PENTASACCHARIDE REPEATING UNIT;

D O I：

10.1002/mas.21471

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

This review is the seventh update of the original article published in 1999 on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2012. General aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, and fragmentation are covered in the first part of the review and applications to various structural types constitute the remainder. The main groups of compound are oligo- and poly-saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals. Much of this material is presented in tabular form. Also discussed are medical and industrial applications of the technique, studies of enzyme reactions, and applications to chemical synthesis. (C) 2015 Wiley Periodicals, Inc.

引用

页码：255 / 422

页数：168

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