Sclerostin levels in CKD patients: an important, but not definitive, step on the way to clinical use

被引：10

作者：

Delanaye, Pierre ^{[1
]}

Cavalier, Etienne ^{[2
]}

Bouquegneau, Antoine ^{[1
]}

Khwaja, Arif ^{[3
]}

机构：

[1] Univ Liege, CHU Sart Tilman, Dept Nephrol, Dialysis,Hypertens,Transplantat, Liege, Belgium

[2] Univ Liege, CHU Sart Tilman, Dept Clin Chem, Liege, Belgium

[3] Sheffield Kidney Inst, Dept Nephrol, Dialysis, Transplantat, Sheffield, S Yorkshire, England

来源：

KIDNEY INTERNATIONAL | 2015年 / 88卷 / 06期

关键词：

BONE-MINERAL DENSITY; CIRCULATING SCLEROSTIN;

D O I：

10.1038/ki.2015.258

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Sclerostin, an inhibitor of the Wnt signaling pathway, inhibits bone formation. In a study of vascular biopsies of patients undergoing kidney transplantation, Qureshi et al. demonstrate that circulating sclerostin levels are associated with vascular calcification (VC). This adds to an emerging body of literature implicating sclerostin as a key link between chronic kidney disease-mineral and bone disorder and cardiovascular disease. Some confounders of this association remain, and the mechanisms by which sclerostin promotes VC have yet to be elucidated.

引用

页码：1221 / 1223

页数：4

共 9 条

[1] From skeletal to cardiovascular disease in 12 steps-the evolution of sclerostin as a major player in CKD-MBD [J].

Brandenburg, Vincent M. ;

D'Haese, Patrick ;

Deck, Annika ;

Mekahli, Djalila ;

Meijers, Bjorn ;

Neven, Ellen ;

Evenepoel, Pieter .

PEDIATRIC NEPHROLOGY, 2016, 31 (02) :195-206

[2] Sclerostin serum levels correlate positively with bone mineral density and microarchitecture in haemodialysis patients [J].

Cejka, Daniel ;

Jaeger-Lansky, Agnes ;

Kieweg, Heidi ;

Weber, Michael ;

Bieglmayer, Christian ;

Haider, Dominik G. ;

Diarra, Danielle ;

Patsch, Janina M. ;

Kainberger, Franz ;

Bohle, Barbara ;

Haas, Martin .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2012, 27 (01) :226-230

[3] Sclerostin and Dickkopf-1 in Renal Osteodystrophy [J].

Cejka, Daniel ;

Herberth, Johann ;

Branscum, Adam J. ;

Fardo, David W. ;

Monier-Faugere, Marie-Claude ;

Diarra, Danielle ;

Haas, Martin ;

Malluche, Hartmut H. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 6 (04) :877-882

[4] Peritoneal dialysis per se is a risk factor for sclerostin-associated adynamic bone disease [J].

de Oliveira, Rodrigo A. ;

Barreto, Fellype C. ;

Mendes, Monique ;

dos Reis, Luciene M. ;

Castro, Joao Henrique ;

Britto, Zita Maria L. ;

Marques, Igor D. B. ;

Carvalho, Aluizio B. ;

Moyses, Rosa M. ;

Jorgetti, Vanda .

KIDNEY INTERNATIONAL, 2015, 87 (05) :1039-1045

[5] Clinical and Biological Determinants of Sclerostin Plasma Concentration in Hemodialysis Patients [J].

Delanaye, Pierre ;

Krzesinski, Jean-Marie ;

Warling, Xavier ;

Moonen, Martial ;

Smelten, Nicole ;

Medart, Laurent ;

Bruyere, Olivier ;

Reginster, Jean-Yves ;

Pottel, Hans ;

Cavalier, Etienne .

NEPHRON CLINICAL PRACTICE, 2014, 128 (1-2) :127-134

[6] Association of Circulating Sclerostin With Bone Mineral Mass, Microstructure, and Turnover Biochemical Markers in Healthy Elderly Men and Women [J].

Durosier, Claire ;

van Lierop, Antoon ;

Ferrari, Serge ;

Chevalley, Thierry ;

Papapoulos, Socrates ;

Rizzoli, Rene .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (09) :3873-3883

[7] Bone Mineral Density and Serum Biochemical Predictors of Bone Loss in Patients with CKD on Dialysis [J].

Malluche, Hartmut H. ;

Davenport, Daniel L. ;

Cantor, Tom ;

Monier-Faugere, Marie-Claude .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 9 (07) :1254-1262

[8] Increased circulating sclerostin levels in end-stage renal disease predict biopsy-verified vascular medial calcification and coronary artery calcification [J].

Qureshi, Abdul Rashid ;

Olauson, Hannes ;

Witasp, Anna ;

Haarhaus, Mathias ;

Brandenburg, Vincent ;

Wernerson, Annika ;

Lindholm, Bengt ;

Soderberg, Magnus ;

Wennberg, Lars ;

Nordfors, Louise ;

Ripsweden, Jonaz ;

Barany, Peter ;

Stenvinkel, Peter .

KIDNEY INTERNATIONAL, 2015, 88 (06) :1356-1364

[9] Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin [J].

Robling, Alexander G. ;

Niziolek, Paul J. ;

Baldridge, Lee A. ;

Condon, Keith W. ;

Allen, Matthew R. ;

Alam, Imranul ;

Mantila, Sara M. ;

Gluhak-Heinrich, Jelica ;

Bellido, Teresita M. ;

Harris, Stephen E. ;

Turner, Charles H. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (09) :5866-5875

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