Synthesis of highly substituted N-hydroxyindoles through 1,5-addition of carbon nucleophiles to in situ generated unsaturated nitrones

被引：38

作者：

Nicolaou, K. C.

Estrada, Anthony A.

Lee, Sang Hyup

Freestone, Graeme C.

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 32期

关键词：

N-hydroxyindoles; nitrogen heterocycles; silanes; stannanes; synthetic methods;

D O I：

10.1002/anie.200601808

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) As easy as 1→2→3: Generation (1→2) and subsequent capture (2→3) of the reactive α,β-unsaturated nitrone species 2 with silyl enol ethers, silanes, and stannanes leads to a facile and direct entry to a variety of highly substituted N-hydroxyindoles 3 through carbon-carbon bond formation. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：5364 / 5368

页数：5

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