TGF-β signaling and the fibrotic response

被引：1965
作者：
Leask, A [1 ]
Abraham, DJ [1 ]
机构：
[1] UCL Royal Free & Univ Coll Med Sch, Dept Med, Ctr Rheumatol, London NW3 2PF, England
来源：
FASEB JOURNAL | 2004年 / 18卷 / 07期
关键词：
Smad; MAP kinase; CTGF; prostacyclin; TNF-alpha; scleroderma; ED-A fibronectin;
D O I：
10.1096/fj.03-1273rev
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cause of fibrotic diseases, pathologies characterized by excessive production, deposition, and contraction of extracellular matrix, is unknown. To understand the molecular basis of fibrotic disease, it is essential to appreciate how matrix deposition is normally controlled and how this process is dysregulated in fibrogenesis. This review discusses the current state of knowledge concerning interactions among the profibrotic proteins transforming growth factor-beta (TGF-beta), connective tissue growth factor (CTGF, CCN2), and ED-A fibronectin (ED- A FN) and the antifibrotic proteins tumor necrosis factor-alpha (TNF-alpha) and gamma-interferon (IFN-gamma).
引用
收藏
页码：816 / 827
页数：12
相关论文
共 151 条
  • [1] Tumor necrosis factor α suppresses the induction of connective tissue growth factor by transforming growth factor-β in normal and scleroderma fibroblasts
    Abraham, DJ
    Xu, SW
    Black, CM
    Sa, S
    Xu, YL
    Leask, A
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (20) : 15220 - 15225
  • [2] Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β
    Abreu, JG
    Ketpura, NI
    Reversade, B
    De Robertis, EM
    [J]. NATURE CELL BIOLOGY, 2002, 4 (08) : 599 - 604
  • [3] ALLEN JT, 1909, AM J RESP CELL MOL B, V21, P693
  • [4] Making sense of latent TGFβ activation
    Annes, JP
    Munger, JS
    Rifkin, DB
    [J]. JOURNAL OF CELL SCIENCE, 2003, 116 (02) : 217 - 224
  • [5] Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    Ashcroft, GS
    Yang, X
    Glick, AB
    Weinstein, M
    Letterio, JJ
    Mizel, DE
    Anzano, M
    Greenwell-Wild, T
    Wahl, SM
    Deng, CX
    Roberts, AB
    [J]. NATURE CELL BIOLOGY, 1999, 1 (05) : 260 - 266
  • [6] IMMUNOLOCALIZATION OF TENASCIN AND CELLULAR FIBRONECTINS IN DIVERSE GLOMERULOPATHIES
    ASSAD, L
    SCHWARTZ, MM
    VIRTANEN, I
    GOULD, VE
    [J]. VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, 1993, 63 (05) : 307 - 316
  • [7] Signal transduction by the TGF-β superfamily
    Attisano, L
    Wrana, JL
    [J]. SCIENCE, 2002, 296 (5573) : 1646 - 1647
  • [8] Babic AM, 1999, MOL CELL BIOL, V19, P2958
  • [9] EXPERIMENTAL AND CLINICAL OBSERVATIONS ON THE ROLE OF ENDOGENOUS AND ON THE EFFECT OF EXOGENOUS PROSTACYCLIN IN GASTRIC-MUCOSA - A PERSONAL VIEW
    BALINT, GA
    [J]. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 1994, 46 (01) : 37 - 40
  • [10] Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero
    Ball, DK
    Moussad, EEDA
    Rageh, MAE
    Kemper, SA
    Brigstock, DR
    [J]. REPRODUCTION, 2003, 125 (02) : 271 - 284
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