Novel Prognostic Gene Mutations Identified in Chronic Lymphocytic Leukemia and Their Impact on Clinical Practice

被引：12

作者：

Campregher, Paulo Vidal ^{[1
]}

Hamerschlak, Nelson ^{[1
,2
]}

机构：

[1] Hosp Israelita Albert Einstein, Dept Clin Pathol & Hematol, Sao Paulo, Brazil

[2] Hosp Israelita Albert Einstein, Dept Hematol & Bone Marrow Transplantat, Sao Paulo, Brazil

来源：

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA | 2014年 / 14卷 / 04期

关键词：

B cell; Biological markers; Cancer; Drug resistance; Mutation; STEM-CELL TRANSPLANTATION; NOTCH1; MUTATIONS; RECURRENT MUTATIONS; SOMATIC MUTATIONS; SPLICING FACTOR; SURVIVAL; SF3B1; CLL; FLUDARABINE; TP53;

D O I：

10.1016/j.clml.2013.12.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic lymphocytic leukemia (CLL) is a lymphoid malignancy characterized by progressive accumulation of mature lymphocytes in the peripheral blood, bone marrow, liver, and lymphoid organs. Although most patients with CLL have an insidious clinical course, a subset of cases present with fast evolution and chemotherapy resistance, leading to high morbidity and mortality. Few clinically validated prognostic markers, such as TP53, are available for use in clinical practice to guide treatment decisions. Recently, several novel prognostically relevant molecular markers have been identified in CLL. We conducted a narrative literature review of the latest findings to evaluate the potential inclusion of these markers in the management of CLL cases.

引用

页码：271 / 276

页数：6

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