The LDL modification hypothesis of atherogenesis: an update

被引：320

作者：

Steinberg, Daniel ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

来源：

JOURNAL OF LIPID RESEARCH | 2009年 / 50卷

关键词：

atherosclerosis; pathogenesis; macrophages; foam cells; fatty streak; clinical trials; antioxidants; 12/15-lipoxygenase; 5-lipoxygenase; animal models; LOW-DENSITY-LIPOPROTEIN; 12/15-LIPOXYGENASE GENE DISRUPTION; OXIDATIVE MODIFICATION HYPOTHESIS; REDUCES CARDIOVASCULAR EVENTS; MIDDLE-AGED INDIVIDUALS; VITAMIN-E; OXIDIZED PHOSPHOLIPIDS; SCAVENGER RECEPTORS; LIPID-PEROXIDATION; DIABETES-MELLITUS;

D O I：

10.1194/jlr.R800087-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The accumulated evidence that oxidative modification of LDL plays an important role in the pathogenesis of atherosclerosis in animal models is very strong. The negative results in recent clinical studies have caused many to conclude that LDL oxidation may not be relevant in the human disease. Yet many of the lines of evidence that support the hypothesis have been demonstrated to apply also in humans. In this review, we briefly summarize the lines of evidence on which the hypothesis rests, its strengths, and its weaknesses.-Steinberg, D. The LDL modification hypothesis of atherogenesis: an update. J. Lipid Res. 2009. S376-S381.

引用

页码：S376 / S381

页数：6

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