Synthesis, Characterization, and Antimicrobial Evaluation of Some Novel 4-Hydroxyquinolin-2(1H)-ones

被引：19

作者：

Ibrahim, Magdy A. ^{[1
]}

Hassanin, Hany M. ^{[1
]}

Alnamer, Youssef A. ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Educ, Dept Chem, Cairo 11711, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2014年 / 44卷 / 23期

关键词：

RORC; Cyclocondensation; pyrano[3,2-c]quinolinone; Vilsmeier-Haack reaction; 4-hydroxyquinolin-2(1H)-one; CHEMICAL BEHAVIOR; NUCLEOPHILIC-REAGENTS; SERIES; ACID; DERIVATIVES;

D O I：

10.1080/00397911.2014.949775

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Vilsmeier-Haack formylation of 3-acetyl-1-methyl-4-hydroxyquinolin-2(1H)-one (2) produced the novel 6-methyl-4,5-dioxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxaldehyde (3). Reactions of carboxaldehyde 3 with a diversity of nucleophilic reagents were studied and a variety of products were obtained via ring-opening, ring-closing (RORC) sequence. Also, some novel heteroannulated pyrano[3,2-c]quinolines were prepared. Structures of the new synthesized products were deduced on the basis of their analytical and spectral data.

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收藏

页码：3470 / 3482

页数：13

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