cASCading specks

被引：13

作者：

Broderick, Lori ^{[1
,2
]}

Hoffman, Hal M. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA

[2] Rady Childrens Hosp San Diego, San Diego, CA USA

[3] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA

来源：

NATURE IMMUNOLOGY | 2014年 / 15卷 / 08期

关键词：

ASC; APOPTOSIS; PROTEIN;

D O I：

10.1038/ni.2942

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammasome-driven inflammation extends into the extracellular space and to neighboring cells through the passive release of specks consisting of the adaptor ASC; this perpetuates the innate immune response and adds a dimension beyond interleukin 1 to autoinflammation.

引用

页码：698 / 700

页数：3

共 10 条

[1] The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
Baroja-Mazo, Alberto
Martin-Sanchez, Fatima
Gomez, Ana I.
Martinez, Carlos M.
Amores-Iniesta, Joaquin
Compan, Vincent
Barbera-Cremades, Maria
Yaguee, Jordi
Ruiz-Ortiz, Estibaliz
Anton, Jordi
Bujan, Segundo
Couillin, Isabelle
Brough, David
Arostegui, Juan I.
Pelegrin, Pablo
[J]. NATURE IMMUNOLOGY, 2014, 15 (08) : 738 - +
[2] Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies
Brydges, Susannah D.
Broderick, Lori
McGeough, Matthew D.
Pena, Carla A.
Mueller, James L.
Hoffman, Hal M.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (11) : 4695 - 4705
[3] Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation
Cai, Xin
Chen, Jueqi
Xu, Hui
Liu, Siqi
Jiang, Qiu-Xing
Halfmann, Randal
Chen, Zhijian J.
[J]. CELL, 2014, 156 (06) : 1207 - 1222
[4] The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
Franklin, Bernardo S.
Bossaller, Lukas
De Nardo, Dominic
Ratter, Jacqueline M.
Stutz, Andrea
Engels, Gudrun
Brenker, Christoph
Nordhoff, Mark
Mirandola, Sandra R.
Al-Amoudi, Ashraf
Mangan, Matthew S.
Zimmer, Sebastian
Monks, Brian G.
Fricke, Martin
Schmidt, Reinhold E.
Espevik, Terje
Jones, Bernadette
Jarnicki, Andrew G.
Hansbro, Philip M.
Busto, Patricia
Marshak-Rothstein, Ann
Hornemann, Simone
Aguzzi, Adriano
Kastenmueller, Wolfgang
Latz, Eicke
[J]. NATURE IMMUNOLOGY, 2014, 15 (08) : 727 - +
[5] Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
Lu, Alvin
Magupalli, Venkat Giri
Ruan, Jianbin
Yin, Qian
Atianand, Maninjay K.
Vos, Matthijn R.
Schroeder, Gunnar F.
Fitzgerald, Katherine A.
Wu, Hao
Egelman, Edward H.
[J]. CELL, 2014, 156 (06) : 1193 - 1206
[6] ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells
Masumoto, J
Taniguchi, S
Ayukawa, K
Sarvotham, H
Kishino, T
Niikawa, N
Hidaka, E
Katsuyama, T
Higuchi, T
Sagara, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (48) : 33835 - 33838
[7] MECHANISMS OF DISEASE Immunodeficiency and Genetic Defects of Pattern-Recognition Receptors
Netea, Mihai G.
van der Meer, Jos W. M.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (01) : 60 - 70
[8] Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis
Richards, N
Schaner, P
Diaz, A
Stuckey, J
Shelden, E
Wadhwa, A
Gumucio, DL
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) : 39320 - 39329
[9] Stutz Andrea, 2013, Methods Mol Biol, V1040, P91, DOI 10.1007/978-1-62703-523-1_8
[10] High Incidence of NLRP3 Somatic Mosaicism in Patients With Chronic Infantile Neurologic, Cutaneous, Articular Syndrome Results of an International Multicenter Collaborative Study
Tanaka, Naoko
Izawa, Kazushi
Saito, Megumu K.
Sakuma, Mio
Oshima, Koichi
Ohara, Osamu
Nishikomori, Ryuta
Morimoto, Takeshi
Kambe, Naotomo
Goldbach-Mansky, Raphaela
Aksentijevich, Ivona
de Saint Basile, Genevieve
Neven, Benedicte
van Gijn, Marielle
Frenkel, Joost
Arostegui, Juan I.
Yaguee, Jordi
Merino, Rosa
Ibanez, Mercedes
Pontillo, Alessandra
Takada, Hidetoshi
Imagawa, Tomoyuki
Kawai, Tomoki
Yasumi, Takahiro
Nakahata, Tatsutoshi
Heike, Toshio
[J]. ARTHRITIS AND RHEUMATISM, 2011, 63 (11): : 3625 - 3632

← 1 →