The role of microglial exosomes in brain injury

被引：11

作者：

Chen, Yahong ^{[1
,2
]}

Zhu, Jie ^{[1
]}

Ji, Jingjing ^{[3
]}

Liu, Zhifeng ^{[3
]}

Ren, Guangli ^{[1
,2
]}

机构：

[1] Gen Hosp Southern Theater Command PLA, Dept Pediat, Guangzhou, Peoples R China

[2] Southern Med Univ, Grad Sch, Guangzhou, Peoples R China

[3] Gen Hosp Southern Theater Command PLA, Dept Crit Care Med, Guangzhou, Peoples R China

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2022年 / 16卷

关键词：

microglia; exosomes; brain injury; regulation; proliferation; apoptosis; TARGETING MICROGLIA; POLARIZATION; CONTRIBUTES; CROSSTALK; BIOLOGY;

D O I：

10.3389/fncel.2022.1003809

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microglia are involved in immune responses to central nervous system (CNS) injury. Meanwhile, exosomes derived from microglia are important mediators of information and material exchange in brain, which play an important role in neuroprotective or damaging effects. Microglial exosomes contain a variety of molecular cargos, including microRNAs, soluble proteins, and lipids, which have regulatory effects on other types of cells and microenvironment in brain. In this review, we summarized microglial exosome characteristics, release patterns, pro-proliferative and pro-apoptotic effects on neurons and other glial cells, immunomodulatory effects, and regulation of the extracellular microenvironment. Understanding the relationship between microglia exosomes and brain injury can provide new targets for clinical treatment.

引用

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