A Lymphotoxin-β-Specific Receptor

被引：357

作者：

Crowe, Paul D. ^{[1
]}

VanArsdale, Todd L. ^{[1
]}

Walter, Barbara N. ^{[1
]}

Ware, Carl F. ^{[1
]}

Hession, Catherine ^{[2
]}

Ehrenfels, Barbara ^{[2
]}

Browning, Jeffrey L. ^{[2
]}

Din, Wenie S. ^{[3
]}

Goodwin, Raymond G. ^{[3
]}

Smith, Craig A. ^{[3
]}

机构：

[1] Univ Calif Riverside, Div Biomed Sci, Riverside, CA 92521 USA

[2] Biogen, Cambridge, MA 02142 USA

[3] Immunex Res & Dev, Seattle, WA 98101 USA

来源：

JOURNAL OF IMMUNOLOGY | 2014年 / 192卷 / 05期

关键词：

TUMOR-NECROSIS-FACTOR; T-CELL; TNF RECEPTOR; EXTRACELLULAR DOMAIN; HETEROMERIC COMPLEX; 33-KDA GLYCOPROTEIN; MICE DEFICIENT; FACTOR-ALPHA; EXPRESSION; PROTEIN;

D O I：

10.1126/science.8171323

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are members of a family of secreted and cell surface cytokines that participate in the regulation of immune and inflammatory responses. The cell surface form of LT-alpha is assembled during biosynthesis as a heteromeric complex with lymphotoxin-beta (LT-beta), a type II transmembrane protein that is another member of the TNF ligand family. Secreted LT-alpha is a homotrimer that binds to distinct TNF receptors of 60 and 80 kilodaltons; however, these receptors do not recognize the major cell surface LT-alpha-LT-beta complex. A receptor specific for human LT-beta was identified, which suggests that cells surface LT may have functions that are distinct from those of secreted LT-alpha

引用

页码：2015 / 2018

页数：4

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