Clinical Significance of Anti-HEV IgA in Diagnosis of Acute Genotype 4 Hepatitis E Virus Infection Negative for Anti-HEV IgM

被引：26

作者：

Zhang, Shujun ^{[1
]}

Tian, Deying ^{[1
]}

Zhang, Zhengang ^{[1
]}

Xiong, Junhui ^{[2
]}

Yuan, Quan ^{[2
]}

Ge, Shengxiang ^{[2
]}

Zhang, Jun ^{[2
]}

Xia, Ningshao ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Infect Dis, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei Province, Peoples R China

[2] Xiamen Univ, Natl Inst Diagnost & Vaccine Dev Infect Dis, Xiamen 361005, Peoples R China

来源：

DIGESTIVE DISEASES AND SCIENCES | 2009年 / 54卷 / 11期

关键词：

Hepatitis E virus; Acute hepatitis E; Anti-HEV IgA; Anti-HEV IgM; Anti-HEV IgG; IMMUNOGLOBULIN-A; ENZYME-IMMUNOASSAY; SERUM SAMPLES; ANTIBODIES; DEFICIENCY; RESPONSES; SEQUENCE; PATIENT; VIREMIA; JAPAN;

D O I：

10.1007/s10620-008-0657-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Anti-HEV IgM is a diagnostic for recent or ongoing HEV infection. However, some patients with acute hepatitis E (AHE) negative for anti-HEV IgM in acute period were often observed in clinical practice. In this study, we constructed the anti-HEV IgA indirect ELISA assay to evaluate the significance of anti-HEV IgA. The specificity of anti-HEV IgA was 99.6%. Among 245 AHE patients, 84 samples from 84 patients were positive for HEV RNA. The positive rate of anti-HEV IgA, anti-HEV IgM and anti-HEV IgG in 84 samples positive for HEV RNA was 96.3, 97.6, and 88.1%, respectively, and no sample was negative for anti-HEV IgA and anti-HEV IgM simultaneously. Among 245 AHE patients, we found nine samples collected from nine patients in acute period were negative for anti-HEV IgM but positive for anti-HEV IgA and two samples were positive for HEV RNA. Detection of anti-HEV IgA can be a useful supplement for diagnosis of acute HEV infection especially in patients negative for anti-HEV IgM.

引用

页码：2512 / 2518

页数：7

共 28 条

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