Modulation of atherogenesis by chemokines

被引:127
作者
Boisvert, WA [1 ]
机构
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Vasc Med Res,Dept Med, Cambridge, MA 02139 USA
关键词
D O I
10.1016/j.tcm.2004.02.006
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Migration of leukocytes into the vasculature-which involves the concerted effort of many molecules, including chemokines-is a requisite step for atherogenesis. The three chemokines that have been implicated most strongly in atherogenesis are monocyte chemoattractant protein 1 (MCP-1), interleukin 8 (IL-8)/growth-regulated oncogene alpha (Gro-alpha), and fractalkine. Although all three chemokines appear to impact atherogenesis by attenuating monocyte/macrophage accumulation in the lesion, the precise mechanism of action of each of the chemokines, as well as their interactive role in atherosclerosis, have not been elucidated. This review focuses on the latest findings that describe the individual roles of MCP-1, IL-8/Gro-alpha, and fractalkine on macrophage recruitment in atherosclerosis. Furthermore, based on present knowledge of the participation of these three chemokines and their receptors in monocyte/macrophage recruitment, a possible interactive role of these chemokines in atherogenesis is explored. (C) 2004, Elsevier Inc.
引用
收藏
页码:161 / 165
页数:5
相关论文
共 42 条
[11]   Atherosclerosis: The road ahead [J].
Glass, CK ;
Witztum, JL .
CELL, 2001, 104 (04) :503-516
[12]   CX3C-chemokine, fractalkine-enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and -independent mechanisms [J].
Goda, S ;
Imai, T ;
Yoshie, O ;
Yoneda, O ;
Inoue, H ;
Nagano, Y ;
Okazaki, T ;
Imai, H ;
Bloom, ET ;
Domae, N ;
Umehara, H .
JOURNAL OF IMMUNOLOGY, 2000, 164 (08) :4313-4320
[13]   MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B [J].
Gosling, J ;
Slaymaker, S ;
Gu, L ;
Tseng, S ;
Zlot, CH ;
Young, SG ;
Rollins, BJ ;
Charo, IF .
JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (06) :773-778
[14]   Linked chromosome 16q13 chemokines, macrophage-derived chemokine, fractalkine, and thymus and activation-regulated chemokine, are expressed in human atherosclerotic lesions [J].
Greaves, DR ;
Häkkinen, T ;
Lucas, AD ;
Liddiard, K ;
Jones, E ;
Quinn, CM ;
Senaratne, J ;
Green, FR ;
Tyson, K ;
Boyle, J ;
Shanahan, C ;
Weissberg, PL ;
Gordon, S ;
Ylä-Hertualla, S .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (06) :923-929
[15]   Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice [J].
Gu, L ;
Okada, Y ;
Clinton, SK ;
Gerard, C ;
Sukhova, GK ;
Libby, P ;
Rollins, BJ .
MOLECULAR CELL, 1998, 2 (02) :275-281
[16]   Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1-mediated chemotaxis in human monocytes - A regulatory role for plasma LDL [J].
Han, KH ;
Tangirala, RK ;
Green, SR ;
Quehenberger, O .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (12) :1983-1991
[17]   Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor γ [J].
Han, KH ;
Chang, MK ;
Boullier, A ;
Green, SR ;
Li, A ;
Glass, CK ;
Quehenberger, O .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (06) :793-802
[18]   Immune mechanisms in atherosclerosis [J].
Hansson, GK .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2001, 21 (12) :1876-1890
[19]   Human vascular smooth muscle cells express receptors for CC chemokines [J].
Hayes, IM ;
Jordan, NJ ;
Towers, S ;
Smith, G ;
Paterson, JR ;
Earnshaw, JJ ;
Roach, AG ;
Westwick, J ;
Williams, RJ .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (03) :397-403
[20]   The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium [J].
Huo, YQ ;
Weber, C ;
Forlow, SB ;
Sperandio, M ;
Thatte, J ;
Mack, M ;
Jung, S ;
Littman, DR ;
Ley, K .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (09) :1307-1314