Duration of COVID-19: Data from an Italian Cohort and Potential Role for Steroids

被引:19
作者
D'Ardes, Damiano [1 ,2 ]
Pontolillo, Michela [2 ,3 ]
Esposito, Lucia [1 ]
Masciarelli, Mara [4 ]
Boccatonda, Andrea [1 ]
Rossi, Ilaria [1 ]
Bucci, Marco [1 ,2 ]
Guagnano, Maria Teresa [1 ,2 ]
Ucciferri, Claudio [2 ,3 ]
Santilli, Francesca [1 ,2 ]
Di Nicola, Marta [5 ]
Falasca, Katia [2 ,3 ]
Vecchiet, Jacopo [2 ,3 ]
Schael, Thomas [2 ]
Cipollone, Francesco [1 ,2 ]
机构
[1] Univ G dAnnunzio, Clin Med Inst, Dept Med & Sci Aging, I-66100 Chieti, Italy
[2] Azienda Sanit Locale 2 Abruzzo Lanciano Vasto Chi, I-66100 Chieti, Italy
[3] Univ G dAnnunzio, Dept Med & Sci Aging, Unit Infect Dis, I-66100 Chieti, Italy
[4] Univ G dAnnunzio, Dept Med & Sci Aging, Unit Hyg & Prevent Med, I-66100 Chieti, Italy
[5] Univ G dAnnunzio, Dept Med Oral & Biotechnol Sci, Lab Biostat, I-66100 Chieti, Italy
关键词
COVID-19; SARS-CoV-2; viral shedding; steroids; SARS-COV-2;
D O I
10.3390/microorganisms8091327
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The diffusion of SARS-CoV-2, starting from China in December 2019, has led to a pandemic, reaching Italy in February 2020. Previous studies in Asia have shown that the median duration of SARS-CoV-2 viral shedding was approximately 12-20 days. We considered a cohort of patients recovered from COVID-19 showing that the median disease duration between onset and end of COVID-19 symptoms was 27.5 days (interquartile range (IQR): 17.0-33.2) and that the median duration between onset of symptoms and microbiological healing, defined by two consecutive negative nasopharyngeal swabs, was 38 days (IQR: 31.7-50.2). A longer duration of COVID-19 with delayed clinical healing (symptom-free) occurred in patients presenting at admission a lower PaO2/FiO(2) ratio (p < 0.001), a more severe clinical presentation (p = 0.001) and a lower lymphocyte count (p = 0.035). Moreover, patients presenting at admission a lower PaO2/FiO(2) ratio and more severe disease showed longer viral shedding (p = 0.031 and p = 0.032, respectively). In addition, patients treated with corticosteroids had delayed clinical healing (p = 0.013).
引用
收藏
页码:1 / 8
页数:9
相关论文
共 26 条
[1]   A Case Series of Children With 2019 Novel Coronavirus Infection: Clinical and Epidemiological Features [J].
Cai Jiehao ;
Xu Jin ;
Lin Daojiong ;
Yang Zhi ;
Xu Lei ;
Qu Zhenghai ;
Zhang Yuehua ;
Zhang Hua ;
Jia Ran ;
Liu Pengcheng ;
Wang Xiangshi ;
Ge Yanling ;
Xia Aimei ;
Tian He ;
Chang Hailing ;
Wang Chuning ;
Li Jingjing ;
Wang Jianshe ;
Zeng Mei .
CLINICAL INFECTIOUS DISEASES, 2020, 71 (06) :1547-1551
[2]   A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster [J].
Chan, Jasper Fuk-Woo ;
Yuan, Shuofeng ;
Kok, Kin-Hang ;
To, Kelvin Kai-Wang ;
Chu, Hin ;
Yang, Jin ;
Xing, Fanfan ;
Liu, Jieling ;
Yip, Cyril Chik-Yan ;
Poon, Rosana Wing-Shan ;
Tsoi, Hoi-Wah ;
Lo, Simon Kam-Fai ;
Chan, Kwok-Hung ;
Poon, Vincent Kwok-Man ;
Chan, Wan-Mui ;
Ip, Jonathan Daniel ;
Cai, Jian-Piao ;
Cheng, Vincent Chi-Chung ;
Chen, Honglin ;
Hui, Christopher Kim-Ming ;
Yuen, Kwok-Yung .
LANCET, 2020, 395 (10223) :514-523
[3]  
Conti P, 2020, J BIOL REG HOMEOS AG, V34, P327, DOI 10.23812/CONTI-E
[4]   Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (Publication with Expression of Concern) [J].
Corman, Victor M. ;
Landt, Olfert ;
Kaiser, Marco ;
Molenkamp, Richard ;
Meijer, Adam ;
Chu, Daniel K. W. ;
Bleicker, Tobias ;
Bruenink, Sebastian ;
Schneider, Julia ;
Schmidt, Marie Luisa ;
Mulders, Daphne G. J. C. ;
Haagmans, Bart L. ;
van der Veer, Bas ;
van den Brink, Sharon ;
Wijsman, Lisa ;
Goderski, Gabriel ;
Romette, Jean-Louis ;
Ellis, Joanna ;
Zambon, Maria ;
Peiris, Malik ;
Goossens, Herman ;
Reusken, Chantal ;
Koopmans, Marion P. G. ;
Drosten, Christian .
EUROSURVEILLANCE, 2020, 25 (03) :23-30
[5]  
D'Ardes Damiano, 2020, Eur J Case Rep Intern Med, V7, P001707, DOI 10.12890/2020_001707
[6]   COVID-19 and RAS: Unravelling an Unclear Relationship [J].
D'Ardes, Damiano ;
Boccatonda, Andrea ;
Rossi, Ilaria ;
Guagnano, Maria Teresa ;
Santilli, Francesca ;
Cipollone, Francesco ;
Bucci, Marco .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (08)
[7]   COVID-19 and Individual Genetic Susceptibility/Receptivity: Role of ACE1/ACE2 Genes, Immunity, Inflammation and Coagulation. Might the Double X-Chromosome in Females Be Protective against SARS-CoV-2 Compared to the Single X-Chromosome in Males? [J].
Gemmati, Donato ;
Bramanti, Barbara ;
Serino, Maria Luisa ;
Secchiero, Paola ;
Zauli, Giorgio ;
Tisato, Veronica .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (10)
[8]   SARS-CoV-2 RNA more readily detected in induced sputum than in throat swabs of convalescent COVID-19 patients [J].
Han, Huanqin ;
Luo, Qingfeng ;
Mo, Fan ;
Long, Lieming ;
Zheng, Weiqiang .
LANCET INFECTIOUS DISEASES, 2020, 20 (06) :655-656
[9]  
He X, 2020, NAT MED, V26, DOI [10.1038/s41591-020-1016-z, 10.1038/s41591-020-0869-5]
[10]   Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients [J].
Lee, N ;
Chan, KCA ;
Hui, DS ;
Ng, EKO ;
Wu, A ;
Chiu, RWK ;
Wong, VWS ;
Chan, PKS ;
Wong, KT ;
Wong, E ;
Cockram, CS ;
Tam, JS ;
Sung, JJY ;
Lo, YD .
JOURNAL OF CLINICAL VIROLOGY, 2004, 31 (04) :304-309