Advanced Glycations End Products in the Skin as Biomarkers of Cardiovascular Risk in Type 2 Diabetes

被引:8
作者
Planas, Alejandra [1 ,2 ]
Simo-Servat, Olga [1 ,2 ]
Hernandez, Cristina [1 ,2 ]
Simo, Rafael [1 ,2 ]
机构
[1] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Vall dHebron Res Inst VHIR, Diabet & Metab Res Unit, Barcelona 08035, Spain
[2] Spanish Inst Hlth ISCIII, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain
关键词
cardiovascular disease; advanced glycation end products; diabetic retinopathy; cardiovascular disease biomarkers; type; 2; diabetes; diabetic complications; CHRONIC KIDNEY-DISEASE; VASCULAR COMPLICATIONS; TOTAL HOMOCYSTEINE; JAPANESE PATIENTS; OXIDATIVE STRESS; SURROGATE MARKER; ERM PROTEINS; AUTOFLUORESCENCE; MELLITUS; RETINOPATHY;
D O I
10.3390/ijms23116234
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The incidence and prevalence of diabetes are increasing worldwide, and cardiovascular disease (CVD) is the leading cause of death among subjects with type 2 diabetes (T2D). The assessment and stratification of cardiovascular risk in subjects with T2D is a challenge. Advanced glycation end products are heterogeneous molecules produced by non-enzymatic glycation of proteins, lipids, or nucleic acids. Accumulation of advanced glycation end products is increased in subjects with T2D and is considered to be one of the major pathogenic mechanism in developing complications in diabetes. Skin AGEs could be assessed by skin autofluorescence. This method has been validated and related to the presence of micro and macroangiopathy in individuals with type 2 diabetes. In this context, the aim of this review is to critically summarize current knowledge and scientific evidence on the relationship between skin AGEs and CVD in subjects with type 2 diabetes, with a brief reference to other diabetes-related complications.
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页数:15
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共 96 条
  • [1] THE IMPACT OF THE TRIAL COORDINATOR IN THE DIABETES CONTROL AND COMPLICATIONS TRIAL (DCCT)
    AHERN, J
    GROVE, N
    STRAND, T
    WESCHE, J
    SEIBERT, C
    BRENNEMAN, AT
    TAMBORLANE, WV
    [J]. DIABETES EDUCATOR, 1993, 19 (06) : 509 - 512
  • [3] Involvement of advanced glycation end product-induced asymmetric dimethylarginine generation in endothelial dysfunction
    Ando, Ryotaro
    Ueda, Seiji
    Yamagishi, Sho-ichi
    Miyazaki, Hiroshi
    Kaida, Yusuke
    Kaifu, Kumiko
    Yokoro, Miyuki
    Nakayama, Yosuke
    Obara, Nana
    Fukami, Kei
    Takeuchi, Masayoshi
    Okuda, Seiya
    [J]. DIABETES & VASCULAR DISEASE RESEARCH, 2013, 10 (05) : 436 - 441
  • [4] [Anonymous], DEMOGRAPHIC GEOGRAPH
  • [5] Skin autofluorescence, renal insufficiency and retinopathy in patients with type 2 diabetes
    Bentata, Rabia
    Cougnard-Gregoire, Audrey
    Delyfer, Marie Noelle
    Delcourt, Cecile
    Blanco, Laurence
    Pupier, Emilie
    Rougier, Marie Benedicte
    Rajaobelina, Kalina
    Hugo, Marie
    Korobelnik, Jean Francois
    Rigalleau, Vincent
    [J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2017, 31 (03) : 619 - 623
  • [6] AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept
    Bierhaus, A
    Hofmann, MA
    Ziegler, R
    Nawroth, PP
    [J]. CARDIOVASCULAR RESEARCH, 1998, 37 (03) : 586 - 600
  • [7] Advanced glycation end-products, measured as skin autofluorescence, associate with vascular stiffness in diabetic, pre-diabetic and normoglycemic individuals: a cross-sectional study
    Birukov, Anna
    Cuadrat, Rafael
    Polemiti, Elli
    Eichelmann, Fabian
    Schulze, Matthias B.
    [J]. CARDIOVASCULAR DIABETOLOGY, 2021, 20 (01)
  • [8] Skin autofluorescence predicts new cardiovascular disease and mortality in people with type 2 diabetes
    Boersma, Henderikus E.
    van Waateringe, Robert P.
    van der Klauw, Melanie M.
    Graaff, Reindert
    Paterson, Andrew D.
    Smit, Andries J.
    Wolffenbuttel, Bruce H. R.
    [J]. BMC ENDOCRINE DISORDERS, 2021, 21 (01)
  • [9] Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study
    Booth, Gillian L.
    Kapral, Moira K.
    Fung, Kinwah
    Tu, Jack V.
    [J]. LANCET, 2006, 368 (9529) : 29 - 36
  • [10] GLYCATION PRODUCTS AND THE PATHOGENESIS OF DIABETIC COMPLICATIONS
    BROWNLEE, M
    [J]. DIABETES CARE, 1992, 15 (12) : 1835 - 1843