Interleukin-12 inhibits apoptosis in chronic lymphatic leukemia (CLL) B cells

被引：6

作者：

Schuhknecht, S

Duensing, S

Dallmann, I

Grosse, J

Reitz, M

Atzpodien, J

机构：

[1] Europaisches Inst Tumor Immunol & Prevent, D-53175 Bonn, Germany

[2] Hannover Med Sch, Hannover, Germany

[3] Univ Munster, Fachklin Hornheide, D-4400 Munster, Germany

来源：

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS | 2002年 / 17卷 / 05期

关键词：

chronic lymphocytic leukemia; apoptosis; cytokines;

D O I：

10.1089/108497802760804718

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The purpose of the present study was to investigate the effect of interleukin-12 on apoptosis of chronic lymphatic leukemia (CLL) B cells. Apoptotic indices were determined in highly purified CD5(+) B lymphocytes isolated from peripheral blood of seven patients with histologically confirmed CLL. Interleukin-4 as a known inhibitor of apoptosis was used as control. Quantitative analysis of apoptosis was determined by cell death detection ELISA. Our findings indicate that interleukin-12 inhibits ex vivo apoptosis in a large proportion of B-CLL patients and may be closely involved in the pathogenesis of disease. Therefore, our results may help identify potential new therapeutic targets in this malignancy.

引用

页码：495 / 499

页数：5

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