Basal ganglia and beyond: The interplay between motor and cognitive aspects in Parkinson's disease rehabilitation

被引：77

作者：

Ferrazzoli, Davide ^{[1
]}

Ortelli, Paola ^{[1
]}

Madeo, Graziella ^{[1
]}

Giladi, Nir ^{[2
]}

Petzinger, Giselle M. ^{[3
,4
]}

Frazzitta, Giuseppe ^{[1
]}

机构：

[1] Moriggia Pelascini Hosp, Dept Parkinsons Dis Movement Disorders & Brain In, Via Pelascini 3, I-22015 Gravedona Ed Uniti, Como, Italy

[2] Tel Aviv Univ, Sagol Sch Neurosci, Sackler Sch Med,Movement Disorders Unit, Tel Aviv Med Ctr,Sieratzki Chair Neurol,Neurol In, Tel Aviv, Israel

[3] Univ Southern Calif, Dept Neurol, Los Angeles, CA 90033 USA

[4] Univ Southern Calif, Div Biokinesiol & Phys Therapy, Los Angeles, CA 90033 USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2018年 / 90卷

关键词：

Parkinson's disease; Rehabilitation; Motor-cognitive interplay; Learning; executive functions; Multidisciplinary approach; RANDOMIZED CONTROLLED-TRIAL; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-LESIONED MOUSE MODEL; INTENSIVE INPATIENT REHABILITATION; DORSOLATERAL PREFRONTAL CORTEX; CEREBELLAR PURKINJE-CELLS; DOPAMINE D2 RECEPTOR; REDUCE FALL RISK; QUALITY-OF-LIFE; PHYSICAL-THERAPY; VIRTUAL-REALITY;

D O I：

10.1016/j.neubiorev.2018.05.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Parkinson's disease (PD) is characterized by motor and cognitive dysfunctions, affecting the motor behaviour. We summarize evidence that the interplay between motor and cognitive approaches is crucial in PD rehabilitation. Rehabilitation is complementary to pharmacological therapy and effective in reducing the PD disturbances, probably acting by inducing neuroplastic effects. The motor behaviour results from a complex integration between cortical and subcortical areas, underlying the motor, cognitive and motivational aspects of movement. The close interplay amongst these areas makes possible to learn, control and express habitual-automatic actions, which are dysfunctional in PD. The physiopathology of PD could be considered the base for the development of effective rehabilitation treatments. As the volitional action control is spared in early-medium stages of disease, rehabilitative approaches engaging cognition permit to achieve motor benefits and appear to be the most effective for PD. We will point out data supporting the relevance of targeting both motor and cognitive aspects in PD rehabilitation. Finally, we will discuss the role of cognitive engagement in motor rehabilitation for PD.

引用

页码：294 / 308

页数：15

共 209 条

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