Natural History of Primary Biliary Cholangitis in the Ursodeoxycholic Acid Era Role of Scoring Systems

被引：31
作者：
Goel, Aparna [1 ]
Kim, Woong Ray [1 ]
机构：
[1] Stanford Univ, Div Gastroenterol & Hepatol, Alway Bldg,Room M211,300 Pasteur Dr, Stanford, CA 94305 USA
来源：
CLINICS IN LIVER DISEASE | 2018年 / 22卷 / 03期
关键词：
PBC; Ursodeoxycholic acid; Prognosis; Scoring systems; Predictive models; RANDOMIZED CONTROLLED-TRIALS; EARLY BIOCHEMICAL RESPONSE; LONG-TERM PROGNOSIS; DOUBLE-BLIND; HISTOLOGICAL PROGRESSION; TREATED PATIENTS; END-POINTS; FOLLOW-UP; CIRRHOSIS; SURVIVAL;
D O I：
10.1016/j.cld.2018.03.007
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Primary biliary cholangitis (PBC) is a chronic disease that progresses to end-stage liver disease. Ursodeoxycholic acid (UDCA), the standard treatment for PBC for several decades, is associated with improved survival without liver transplant. Approximately 40% of patients do not respond to UDCA. Because of disease variability, there exist several prognostic models that incorporate various factors including biochemical response to UDCA. These models are useful for patient care and counseling as well as risk stratification for research and clinical trials, and the role of these models in the pre-UDCA and UDCA eras is discussed.
引用
收藏
页码：563 / +
页数：17
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