In-Vitro Approaches for Studying Blast-Induced Traumatic Brain Injury

被引:95
|
作者
Chen, Yung Chia [1 ]
Smith, Douglas H. [2 ]
Meaney, David F. [1 ,2 ]
机构
[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Neurosurg, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
biomechanics; blast; brain injury; in-vitro models; STRETCH-INDUCED INJURY; INTRACELLULAR FREE CALCIUM; MAMMALIAN SPINAL NEURONS; FINITE-ELEMENT-ANALYSIS; MECHANICAL INJURY; CULTURED ASTROCYTES; AXONAL INJURY; SHELL SHOCK; CELL-DEATH; ULTRASTRUCTURAL-CHANGES;
D O I
10.1089/neu.2008.0645
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Traumatic brain injury caused by explosive or blast events is currently divided into four phases: primary, secondary, tertiary, and quaternary blast injury. These phases of blast-induced traumatic brain injury (bTBI) are biomechanically distinct, and can be modeled in both in-vivo and in-vitro systems. The purpose of this review is to consider the mechanical phases of bTBI, how these phases are reproduced with in-vitro models, and to review findings from these models to assess how each phase of bTBI can be examined in more detail. Highlighted are some important gaps in the literature that may be addressed in the future to better identify the exact contributing mechanisms for bTBI. These in-vitro models, viewed in combination with in-vivo models and clinical studies, can be used to assess both the mechanisms and possible treatments for this type of trauma.
引用
收藏
页码:861 / 876
页数:16
相关论文
共 50 条
  • [41] Relevance of Blood Vessel Networks in Blast-Induced Traumatic Brain Injury
    Hua, Yi
    Lin, Shengmao
    Gu, Linxia
    COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2015, 2015
  • [42] Role of Frontal Sinus on Primary Blast-Induced Traumatic Brain Injury
    Akula, Praveen Kumar
    Hua, Yi
    Gu, Linxia
    JOURNAL OF MEDICAL DEVICES-TRANSACTIONS OF THE ASME, 2013, 7 (03):
  • [43] NEURODEGENERATION FOLLOWING MILD BLAST-INDUCED TRAUMATIC BRAIN INJURY IN RATS
    Beauclair, Timothy
    Rogers, Edmond
    Acosta, Glen
    Race, Nicholas
    Shi, Riyi
    JOURNAL OF NEUROTRAUMA, 2021, 38 (14) : A131 - A131
  • [44] A Wireless Intracranial Brain Deformation Sensing System for Blast-Induced Traumatic Brain Injury
    Song, S.
    Race, N. S.
    Kim, A.
    Zhang, T.
    Shi, R.
    Ziaie, B.
    SCIENTIFIC REPORTS, 2015, 5
  • [45] A Wireless Intracranial Brain Deformation Sensing System for Blast-Induced Traumatic Brain Injury
    S. Song
    N. S. Race
    A. Kim
    T. Zhang
    R. Shi
    B. Ziaie
    Scientific Reports, 5
  • [46] An open air research study of blast-induced traumatic brain injury to goats
    Chen, Hui-Jun
    Xu, Chuan
    Li, Yue
    Chen, Zhi-Qiang
    Li, Guan-Hua
    Duan, Zhao-Xia
    Li, Xiao-Xia
    Zhang, Jie-Yuan
    Wang, Zhe
    Feng, Hua
    Li, Bing-Cang
    CHINESE JOURNAL OF TRAUMATOLOGY, 2015, 18 (05) : 267 - 274
  • [47] Effect of Early Normobaric Hyperoxia on Blast-Induced Traumatic Brain Injury in Rats
    Yanteng Li
    Wenying Lv
    Gang Cheng
    Shuwei Wang
    Bangxin Liu
    Hulin Zhao
    Hongwei Wang
    Leiming Zhang
    Chao Dong
    Jianning Zhang
    Neurochemical Research, 2020, 45 : 2723 - 2731
  • [48] Excitability of the Nociceptive System in Rats after Blast-Induced Traumatic Brain Injury
    Kozlova, Yu. V.
    Demchenko, O. M.
    NEUROPHYSIOLOGY, 2022, 54 (3-4) : 136 - 142
  • [49] CHANGES IN GLUTAMATE RECEPTOR TRAFFICKING IN BLAST-INDUCED TRAUMATIC BRAIN INJURY IN THE RAT
    Wang, Yushan
    Chavko, Mikulas
    Weiss, Tracy
    Adeeb, Saleena
    McCarron, Richard
    Yu, Simon
    JOURNAL OF NEUROTRAUMA, 2011, 28 (06) : A48 - A48
  • [50] Review on Mechanical Mechanism of Blast-induced Traumatic Brain Injury and Protection Technology
    Cai Z.
    He W.
    Wang J.
    Wang X.
    Zhang L.
    Binggong Xuebao/Acta Armamentarii, 2022, 43 (02): : 467 - 480