SYNTHESIS, CHARACTERIZATION, DNA BINDING, AND ANTICANCER ABILITY OF A Co(II) COMPLEX CONSTRUCTED BY 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYLIC ACID

被引：0
作者：
Wu, S. [1 ,2 ]
Wang, S. [1 ,2 ]
Zhu, M. [1 ,2 ]
Gao, E. [1 ,2 ,3 ]
机构：
[1] Shenyang Univ Chem Technol, Key Lab Liaoning Inorgan Mol Based Chem, Shenyang, Peoples R China
[2] Shenyang Univ Chem Technol, Dept Coordinat Chem, Shenyang, Peoples R China
[3] Univ Sci & Technol Liaoning, Sch Chem Engn, Anshan, Peoples R China
来源：
JOURNAL OF STRUCTURAL CHEMISTRY | 2020年 / 61卷 / 12期
关键词：
DNA binding; apoptotic; crystal structure; IN-VITRO; CRYSTAL-STRUCTURES; CYTOTOXICITY; DERIVATIVES;
D O I：
10.1134/S0022476620120112
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The Co(II) complex based on 2-propyl-1H-imidazole-4,5-dicarboxy acid (H2L) is synthesized and characterized. The interaction between the Co complex and fish sperm DNA(FS-DNA) are studied by fluorescence. The flow cytometry analysis shows that the Co complex can induce the apoptosis of HeLa (human cervix epithelia carcinoma cells) tumor cell lines. According to the fluorescence and apoptosis effects, it is speculated that the compound has a potential application value in the field of anticancer agents, and its properties need to be further explored.
引用
收藏
页码：1938 / 1944
页数：7
相关论文
共 50 条
[31]   Syntheses, characterization, interaction with DNA, cytotoxic and apoptosis of two novel complexes of Zn(II) and Mn(II) with 2-methyl-1H-4,5-imidazoledicarboxylic acid [J].
Li, Ling-Feng ;
Wang, Han ;
Zhang, Jie ;
Ma, Chi ;
Li, Ying-Ying ;
Wang, Lu ;
Liang, Shi-Kai ;
Jin, Hai-Tao ;
Liu, Si-Jia ;
Zhu, Ming-Chang ;
Gao, En-Jun .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 92 :295-301
[32]   Synthesis and characterisation of Mn(II), Co(II) and Cd(II) coordination polymers of 1,2,4-triazole-3, 5-dicarboxylic acid [J].
Ma, Qi ;
Zhu, Miaoli ;
Lu, Liping ;
Feng, Sisi ;
Wang, Tianwei .
DALTON TRANSACTIONS, 2010, 39 (25) :5877-5884
[33]   Syntheses, crystal structures, and fluorescent properties of two Cd(II) complexes based on 2,2′-(ethane-1,2-diyl)bis(1H-imidazole-4,5-dicarboxylic acid) [J].
Li, Ting ;
Xiu, Yu ;
Su, Xiao ;
Meng, Xiang-Ru .
JOURNAL OF COORDINATION CHEMISTRY, 2012, 65 (17) :3111-3121
[34]   A New 3D Layered-pillared Cobalt(II)-organic Framework Constructed by Imidazole-4,5-dicarboxylic Acid (H3IDC) and 4,4′-Bipyridine (bipy) [J].
Yuan Li ;
Lu Wen-Guan .
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2011, 30 (08) :1207-1213
[35]   Synthesis, Crystal Structure, and Luminescent Property of a New 3D Cd(II) Coordination Polymer Constructed from Imidazole-4,5-dicarboxylic Acid and 1,4-Bis(imidazol-1-ylmethyl)benzene Ligands [J].
Liu Hong-Wen ;
Lu Wen-Guan .
CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2011, 27 (01) :152-156
[36]   Two complexes based on 1H-1,2,3-triazole-4,5-dicarboxylic acid: hydrothermal synthesis, crystal structures and spectral properties [J].
Tong, Xiao-Lan ;
Xin, Jian-Hua ;
Guo, Wei-Hua ;
Zhu, Xia-Ping .
JOURNAL OF COORDINATION CHEMISTRY, 2011, 64 (17) :2984-2994
[37]   A new 3-D Cd(II) coordination polymer with metallacalix[4]arene building blocks based on 2-(pyridin-2-yl)-1H-imidazole-4,5-dicarboxylic acid [J].
Yu, Xiao-Yang ;
Zhang, Xiao ;
Qu, Xiao-Shu ;
Ma, Ming-Shuo ;
Liu, Zhi-Gang ;
Jin, Li ;
Yang, Yan-Yan ;
Luo, Ya-Nan .
JOURNAL OF COORDINATION CHEMISTRY, 2015, 68 (20) :3580-3588
[38]   Anticancer activity: synthesis, characterization and DNA binding of a 1,2,4-triazole-based Zn(III) complex [J].
Gnanadeepam, Yakkobu ;
Shankar, Bhaskaran ;
Tamilselvi, Arunachalam .
NEW JOURNAL OF CHEMISTRY, 2025, 49 (20) :8215-8224
[39]   Synthesis and structures of two novel non-centrosymmetric metal-organic polymers containing 2-(pyridin-4-yl)-1H-imidazole-4,5-dicarboxylic acid ligands [J].
Chen, Li-Zhuang ;
Huang, Yao ;
Xiong, Ren-Gen ;
Hu, Hong-Wen .
JOURNAL OF MOLECULAR STRUCTURE, 2010, 963 (01) :16-21
[40]   Synthesis, crystal structure, and BSA binding studies of new Co(II) and Ni(II) complexes of 2-(hydroxymethyl)-1H-imidazole-4,5-dicarboxylate [J].
Li, Xiao-Fei ;
Yang, Yan-Qiu ;
Li, Ya-Xue ;
Yang, Huai-Xia ;
Zhao, Wen-Feng ;
Meng, Xiang-Ru .
INORGANICA CHIMICA ACTA, 2020, 505
12345