SYNTHESIS, CHARACTERIZATION, DNA BINDING, AND ANTICANCER ABILITY OF A Co(II) COMPLEX CONSTRUCTED BY 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYLIC ACID

被引：0
作者：
Wu, S. [1 ,2 ]
Wang, S. [1 ,2 ]
Zhu, M. [1 ,2 ]
Gao, E. [1 ,2 ,3 ]
机构：
[1] Shenyang Univ Chem Technol, Key Lab Liaoning Inorgan Mol Based Chem, Shenyang, Peoples R China
[2] Shenyang Univ Chem Technol, Dept Coordinat Chem, Shenyang, Peoples R China
[3] Univ Sci & Technol Liaoning, Sch Chem Engn, Anshan, Peoples R China
来源：
JOURNAL OF STRUCTURAL CHEMISTRY | 2020年 / 61卷 / 12期
关键词：
DNA binding; apoptotic; crystal structure; IN-VITRO; CRYSTAL-STRUCTURES; CYTOTOXICITY; DERIVATIVES;
D O I：
10.1134/S0022476620120112
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The Co(II) complex based on 2-propyl-1H-imidazole-4,5-dicarboxy acid (H2L) is synthesized and characterized. The interaction between the Co complex and fish sperm DNA(FS-DNA) are studied by fluorescence. The flow cytometry analysis shows that the Co complex can induce the apoptosis of HeLa (human cervix epithelia carcinoma cells) tumor cell lines. According to the fluorescence and apoptosis effects, it is speculated that the compound has a potential application value in the field of anticancer agents, and its properties need to be further explored.
引用
收藏
页码：1938 / 1944
页数：7
相关论文
共 50 条
  • [21] Three new metal-organic frameworks based on 2-propyl-1H-imidazole-4,5-dicarboxylate: Synthesis, crystal structure and luminescent properties
    Fan, Rui-Qing
    Wang, Li-Yuan
    Chen, Hong
    Zhou, Guang-Peng
    Yang, Yu-Lin
    Hasi, Wuliji
    Cao, Wen-Wu
    POLYHEDRON, 2012, 33 (01) : 90 - 96
  • [22] Crystal structure, DNA binding, cytotoxicity and anticancer ability of Zn(II) complex constructed by 2-(1,2,4)triazol-1-yl-isonicotinic acid
    Zhu, Mingchang
    Ji, Xiaoxi
    Wang, Songling
    Zhou, Yi
    Bao, Huahong
    Li, Shuhan
    Gao, Enjun
    Wu, Shuangyan
    Wang, Jing
    Chen, Qing
    Xu, Jin
    Zhu, Xiaopeng
    INORGANIC CHEMISTRY COMMUNICATIONS, 2021, 128
  • [23] Assembly of a 2D Cd(II) Coordination Polymer from a New Multidentate Ligand 2-((1H-Tetrazol-5-yl)methyl)-1H-imidazole-4,5-dicarboxylic acid
    Cai, Qiang
    You, Xuehai
    Su, Jun
    Tang, Weibin
    JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 2024, 54 (01) : 9 - 17
  • [24] A New 2D Zinc(Ⅱ) Coordination Polymer Constructed by Imidazole-4,5-dicarboxylic Acid(H3IDC) and 1,4-Bis(imidazol-1-ylmethyl)-benzene(bix)
    刘宏文
    卢文贯
    结构化学, 2010, 29 (09) : 1416 - 1420
  • [25] The coordination chemistry of N-heterocyclic carboxylic acid: A comparison of the coordination polymers constructed by 4,5-imidazoledicarboxylic acid and 1H-1,2,3-triazole-4,5-dicarboxylic acid
    Zhang, Shaowei
    Shi, Wei
    Cheng, Peng
    COORDINATION CHEMISTRY REVIEWS, 2017, 352 : 108 - 150
  • [26] Assembly of a 2D Cd(II) Coordination Polymer from a New Multidentate Ligand 2-((1H-Tetrazol-5-yl)methyl)-1H-imidazole-4,5-dicarboxylic acid
    Qiang Cai
    Xuehai You
    Jun Su
    Weibin Tang
    Journal of Chemical Crystallography, 2024, 54 (1) : 9 - 17
  • [27] Synthesis, DNA binding, apoptosis and molecular docking of a Mn(II) complex constructed by 2-(1,2,4-Triazol-1-yl)-4-picolinic acid
    Li, Yong
    Ji, Xiaoxi
    Wu, Shuangyan
    Zhang, Ying
    Zhu, Mingchang
    Gao, Enjun
    INORGANIC CHEMISTRY COMMUNICATIONS, 2021, 133
  • [28] Cadmium(II) complex with 2-methyl-1H-4,5-imidazoledicarboxylic acid ligand: synthesis, characterization, and biological activity
    Ma, Chi
    Liang, Shi-Kai
    Zhao, Fu-Chen
    Meng, Yang
    Li, Ying-Ying
    Zhu, Ming-Chang
    Gao, En-Jun
    JOURNAL OF COORDINATION CHEMISTRY, 2014, 67 (21) : 3551 - 3564
  • [29] Lanthanide contraction effect on the crystal structures of 2D lanthanide coordination polymers based on 2-(trifluoromethyl)-1H-imidazole-4,5-dicarboxylic acid
    Cai, Song-Liang
    Zhang, Kai
    Wang, Sha
    Wang, Zhen-Nan
    Feng, Min-Xue
    Li, Le-Bin
    Fan, Jun
    Zheng, Sheng-Run
    Zhang, Wei-Guang
    STRUCTURAL CHEMISTRY, 2017, 28 (03) : 577 - 586
  • [30] Lanthanide contraction effect on the crystal structures of 2D lanthanide coordination polymers based on 2-(trifluoromethyl)-1H-imidazole-4,5-dicarboxylic acid
    Song-Liang Cai
    Kai Zhang
    Sha Wang
    Zhen-Nan Wang
    Min-Xue Feng
    Le-Bin Li
    Jun Fan
    Sheng-Run Zheng
    Wei-Guang Zhang
    Structural Chemistry, 2017, 28 : 577 - 586
12345