SYNTHESIS, CHARACTERIZATION, DNA BINDING, AND ANTICANCER ABILITY OF A Co(II) COMPLEX CONSTRUCTED BY 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYLIC ACID

被引：0
作者：
Wu, S. [1 ,2 ]
Wang, S. [1 ,2 ]
Zhu, M. [1 ,2 ]
Gao, E. [1 ,2 ,3 ]
机构：
[1] Shenyang Univ Chem Technol, Key Lab Liaoning Inorgan Mol Based Chem, Shenyang, Peoples R China
[2] Shenyang Univ Chem Technol, Dept Coordinat Chem, Shenyang, Peoples R China
[3] Univ Sci & Technol Liaoning, Sch Chem Engn, Anshan, Peoples R China
来源：
JOURNAL OF STRUCTURAL CHEMISTRY | 2020年 / 61卷 / 12期
关键词：
DNA binding; apoptotic; crystal structure; IN-VITRO; CRYSTAL-STRUCTURES; CYTOTOXICITY; DERIVATIVES;
D O I：
10.1134/S0022476620120112
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The Co(II) complex based on 2-propyl-1H-imidazole-4,5-dicarboxy acid (H2L) is synthesized and characterized. The interaction between the Co complex and fish sperm DNA(FS-DNA) are studied by fluorescence. The flow cytometry analysis shows that the Co complex can induce the apoptosis of HeLa (human cervix epithelia carcinoma cells) tumor cell lines. According to the fluorescence and apoptosis effects, it is speculated that the compound has a potential application value in the field of anticancer agents, and its properties need to be further explored.
引用
收藏
页码：1938 / 1944
页数：7
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