Borrelia burgdorferi outer surface protein (osp) B expression independent of ospA

被引：17
作者：
Liang, FT
Caimano, MJ
Radolf, JD
Fikrig, E
机构：
[1] Yale Univ, Sch Med, Dept Internal Med, Rheumatol Sect, New Haven, CT 06520 USA
[2] Univ Connecticut, Hlth Sci Ctr, Dept Pathol, Farmington, CT 06030 USA
[3] Univ Connecticut, Hlth Sci Ctr, Dept Med, Farmington, CT 06030 USA
[4] Univ Connecticut, Hlth Sci Ctr, Dept Genet & Dev Biol, Farmington, CT 06030 USA
[5] Univ Connecticut, Hlth Sci Ctr, Ctr Microbial Pathogenesis, Farmington, CT 06030 USA
来源：
MICROBIAL PATHOGENESIS | 2004年 / 37卷 / 01期
关键词：
Lyme disease; Borrelia burgdorferi; arthritis; inflammation;
D O I：
10.1016/j.micpath.2004.02.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The outer surface proteins (Osp) A and B are two important lipoproteins of Borrelia burgdorferi, the Lyme disease spirochete. Extensive in vitro studies indicate that ospB shares a common promoter with ospA and thus these two lipoprotein genes are coordinately transcribed. We show here that B. burgdorferi expresses ospB at much higher levels than ospA during experimental murine infection. The ratio of ospA and ospB mRNA transcripts was 3.5:1 in tick-adapted spirochetes while B. burgdorferi matched every os A mRNA with up to 70 ospB transcripts during murine infection. This was consistent with the analysis of antibody responses to the two lipoproteins, which showed a more frequent Osp13 response than OspA during chronic murine infection. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：35 / 40
页数：6
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