Enterococcus phage Nonaheksakonda infecting clinical isolates of Enterococcus faecalis represents a new lineage in the family Siphoviridae

被引：8

作者：

Olsen, Nikoline S. ^{[1
,2
]}

Nielsen, Katrine Johansen ^{[1
]}

Ploger, Maja ^{[1
]}

Kot, Witold ^{[1
]}

Hansen, Lars Hestbjerg ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Plant & Environm Sci, Thorvaldsensvej 40, DK-1871 Frederiksberg, Denmark

[2] Aarhus Univ, Dept Environm Sci, Frederiksborgvej 399, DK-4000 Roskilde, Denmark

来源：

ARCHIVES OF VIROLOGY | 2021年 / 166卷 / 02期

关键词：

COMPLETE GENOME SEQUENCE; BACTERIOPHAGE; RESISTANCE; PREDICTION; COMMENSALS; VIRULENCE; SEARCH; GENES;

D O I：

10.1007/s00705-020-04905-y

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Enterococcus phage Nonaheksakonda was isolated from wastewater, using a vancomycin-resistant strain of the opportunistic pathogen Enterococcus faecalis (VRE) as a host. Nonaheksakonda is a lytic phage infecting E. faecalis V583 and clinical isolates with at least four different multi-locus sequence types (MLSTs). The genome is a 41.9-kb double-stranded DNA molecule (34.6% GC) with 74 coding sequences. Comparative analysis revealed only one close relative, Enterococcus phage heks. All other phages had low protein similarity and shared less than 54% nucleotide sequence identity with phage Nonaheksakonda. The most similar phages were all classified and unclassified efquatroviruses. We propose that the phages Nonaheksakonda and heks represent a novel genus within the family Siphoviridae, order Caudovirales, for which we propose the name "Nonaheksakondavirus".

引用

页码：593 / 599

页数：7