A Novel Live-Attenuated Vaccine Candidate for Mayaro Fever

被引：52
|
作者：
Weise, William J. [1 ]
Hermance, Meghan E.
Forrester, Naomi
Adams, A. Paige
Langsjoen, Rose
Gorchakov, Rodion
Wang, Eryu
Alcorn, Maria D. H.
Tsetsarkin, Konstantin
Weaver, Scott C.
机构：
[1] Univ Texas Med Branch, Inst Human Infect & Immun, Ctr Trop Dis, Galveston, TX 77555 USA
来源：
PLOS NEGLECTED TROPICAL DISEASES | 2014年 / 8卷 / 08期
基金：
美国国家卫生研究院;
关键词：
EQUINE ENCEPHALITIS-VIRUS; CHIKUNGUNYA VIRUS; CYNOMOLGUS MACAQUES; ENCEPHALOMYELITIS VIRUS; NONHUMAN-PRIMATES; AMAZON BASIN; INFECTION; DISEASE; STRAIN; ALPHAVIRUSES;
D O I：
10.1371/journal.pntd.0002969
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Mayaro virus (MAYV) is an emerging, mosquito-borne alphavirus that causes a dengue-like illness in many regions of South America, and which has the potential to urbanize. Because no specific treatment or vaccine is available for MAYV infection, we capitalized on an IRES-based approach to develop a live-attenuated MAYV vaccine candidate. Testing in infant, immunocompetent as well as interferon receptor-deficient mice demonstrated a high degree of attenuation, strong induction of neutralizing antibodies, and efficacy against lethal challenge. This vaccine strain was also unable to infect mosquito cells, a major safety feature for a live vaccine derived from a mosquito-borne virus. Further preclinical development of this vaccine candidate is warranted to protect against this important emerging disease.
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页数：9
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