Future treatments of cirrhosis

被引：16
作者：
Tsochatzis, Emmanuel A. [1 ,2 ]
Bosch, Jaime [3 ,4 ]
Burroughs, Andrew K. [1 ,2 ]
机构：
[1] Royal Free Hosp, Royal Free Sheila Sherlock Liver Ctr, London NW3 2QG, England
[2] UCL Inst Liver & Digest Hlth, London, England
[3] Univ Barcelona, Hosp Clin IDIBAPS, Hepat Hemodynam Lab, Barcelona, Spain
[4] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
来源：
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2014年 / 8卷 / 05期
关键词：
anticoagulation; b-blockers; cirrhosis; hepatocellular carcinoma; metformin; mortality; prevention; statins; warfarin; PORTAL-VEIN THROMBOSIS; CHRONIC LIVER-DISEASE; CHRONIC HEPATITIS-C; SUSTAINED VIROLOGICAL RESPONSE; METABOLIC SYNDROME INCREASES; HEPATOCELLULAR-CARCINOMA; VIRAL-HEPATITIS; RIFAXIMIN IMPROVES; INSULIN-RESISTANCE; SEVERE FIBROSIS;
D O I：
10.1586/17474124.2014.902303
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Cirrhosis can be sub-classified in clinical stages with distinct differences in prognosis and can even be reversed in some cases with successful etiological treatment. In this article, we review potential future therapies of cirrhosis, mainly focusing in the expansion of indications of currently licensed drugs. We strongly advocate that future therapies should focus on preventing the advent of complications and further progression of liver disease and should involve both primary and secondary care physicians. Such strategies could be based on the combination of currently licensed, relatively safe and inexpensive drugs and such randomized controlled trials should be prioritized in patients with advanced liver disease. The paradigm should be similar to that of prevention in cardiovascular diseases and long-term follow-up trials are needed.
引用
收藏
页码：571 / 581
页数：11
相关论文
共 101 条
[21]   Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies [J].
D'Amico, G ;
Garcia-Tsao, G ;
Pagliaro, L .
JOURNAL OF HEPATOLOGY, 2006, 44 (01) :217-231
[22]   Referral and Receipt of Treatment for Hepatocellular Carcinoma in United States Veterans: Effect of Patient and Nonpatient Factors [J].
Davila, Jessica A. ;
Kramer, Jennifer R. ;
Duan, Zhigang ;
Richardson, Peter A. ;
Tyson, Gia L. ;
Sada, Yvonne H. ;
Kanwal, Fasiha ;
El-Serag, Hashem B. .
HEPATOLOGY, 2013, 57 (05) :1858-1868
[23]   Statins Are Associated With a Reduced Risk of Hepatocellular Carcinoma in a Large Cohort of Patients With Diabetes [J].
El-Serag, Hashem B. ;
Johnson, Michael L. ;
Hachem, Christine ;
Morgana, Robert O. .
GASTROENTEROLOGY, 2009, 136 (05) :1601-1608
[24]   Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma [J].
El-Serag, HB ;
Tran, T ;
Everhart, JE .
GASTROENTEROLOGY, 2004, 126 (02) :460-468
[25]   A Randomized Controlled Trial of Pretransplant Antiviral Therapy to Prevent Recurrence of Hepatitis C After Liver Transplantation [J].
Everson, Gregory T. ;
Terrault, Norah A. ;
Lok, Anna S. ;
Rodrigo, Del R. ;
Brown, Robert S., Jr. ;
Saab, Sammy ;
Shiffman, Mitchell L. ;
Al-Osaimi, Abdullah M. S. ;
Kulik, Laura M. ;
Gillespie, Brenda W. ;
Everhart, James E. .
HEPATOLOGY, 2013, 57 (05) :1752-1762
[26]   Renal failure and cirrhosis: A systematic review of mortality and prognosis [J].
Fede, Giuseppe ;
D'Amico, Gennaro ;
Arvaniti, Vasiliki ;
Tsochatzis, Emmanuel ;
Germani, Giacomo ;
Georgiadis, Dimosthenis ;
Morabito, Alberto ;
Burroughs, Andrew Kenneth .
JOURNAL OF HEPATOLOGY, 2012, 56 (04) :810-818
[27]   Bacterial infections in cirrhosis:: Epidemiological changes with invasive procedures and norfloxacin prophylaxis [J].
Fernández, J ;
Navasa, M ;
Gómez, J ;
Colmenero, J ;
Vila, J ;
Arroyo, V ;
Rodés, J .
HEPATOLOGY, 2002, 35 (01) :140-148
[28]   National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants [J].
Finucane, Mariel M. ;
Stevens, Gretchen A. ;
Cowan, Melanie J. ;
Danaei, Goodarz ;
Lin, John K. ;
Paciorek, Christopher J. ;
Singh, Gitanjali M. ;
Gutierrez, Hialy R. ;
Lu, Yuan ;
Bahalim, Adil N. ;
Farzadfar, Farshad ;
Riley, Leanne M. ;
Ezzati, Majid .
LANCET, 2011, 377 (9765) :557-567
[29]   Now There Are Many (Stages) Where Before There Was One: In Search of a Pathophysiological Classification of Cirrhosis [J].
Garcia-Tsao, Guadalupe ;
Friedman, Scott ;
Iredale, John ;
Pinzani, Massimo .
HEPATOLOGY, 2010, 51 (04) :1445-1449
[30]   Current Concepts: Management of Varices and Variceal Hemorrhage in Cirrhosis. [J].
Garcia-Tsao, Guadalupe ;
Bosch, Jaime .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (09) :823-832
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