Future treatments of cirrhosis

被引：16

作者：

Tsochatzis, Emmanuel A. ^{[1
,2
]}

Bosch, Jaime ^{[3
,4
]}

Burroughs, Andrew K. ^{[1
,2
]}

机构：

[1] Royal Free Hosp, Royal Free Sheila Sherlock Liver Ctr, London NW3 2QG, England

[2] UCL Inst Liver & Digest Hlth, London, England

[3] Univ Barcelona, Hosp Clin IDIBAPS, Hepat Hemodynam Lab, Barcelona, Spain

[4] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2014年 / 8卷 / 05期

关键词：

anticoagulation; b-blockers; cirrhosis; hepatocellular carcinoma; metformin; mortality; prevention; statins; warfarin; PORTAL-VEIN THROMBOSIS; CHRONIC LIVER-DISEASE; CHRONIC HEPATITIS-C; SUSTAINED VIROLOGICAL RESPONSE; METABOLIC SYNDROME INCREASES; HEPATOCELLULAR-CARCINOMA; VIRAL-HEPATITIS; RIFAXIMIN IMPROVES; INSULIN-RESISTANCE; SEVERE FIBROSIS;

D O I：

10.1586/17474124.2014.902303

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Cirrhosis can be sub-classified in clinical stages with distinct differences in prognosis and can even be reversed in some cases with successful etiological treatment. In this article, we review potential future therapies of cirrhosis, mainly focusing in the expansion of indications of currently licensed drugs. We strongly advocate that future therapies should focus on preventing the advent of complications and further progression of liver disease and should involve both primary and secondary care physicians. Such strategies could be based on the combination of currently licensed, relatively safe and inexpensive drugs and such randomized controlled trials should be prioritized in patients with advanced liver disease. The paradigm should be similar to that of prevention in cardiovascular diseases and long-term follow-up trials are needed.

引用

页码：571 / 581

页数：11

共 101 条

[1] Simvastatin Lowers Portal Pressure in Patients With Cirrhosis and Portal Hypertension: A Randomized Controlled Trial [J].

Abraldes, Juan G. ;

Albillos, Agustin ;

Banares, Rafael ;

Turnes, Juan ;

Gonzalez, Rosario ;

Garcia-Pagan, Juan Carlos ;

Bosch, Jaime .

GASTROENTEROLOGY, 2009, 136 (05) :1651-1658

[2]

[Anonymous], 2012, Prevention and control of viral hepatitis infection: framework for global action

[3]

[Anonymous], J HEPATOL

[4]

[Anonymous], CLIN GASTROENTEROL H

[5] Infections in Patients With Cirrhosis Increase Mortality Four-Fold and Should Be Used in Determining Prognosis [J].

Arvaniti, Vasiliki ;

D'Amico, Gennaro ;

Fede, Giuseppe ;

Manousou, Pinelopi ;

Tsochatzis, Emmanuel ;

Pleguezuelo, Maria ;

Burroughs, Andrew Kenneth .

GASTROENTEROLOGY, 2010, 139 (04) :1246-+

[6] Underestimation of Liver-Related Mortality in the United States [J].

Asrani, Sumeet K. ;

Larson, Joseph J. ;

Yawn, Barbara ;

Therneau, Terry M. ;

Kim, W. Ray .

GASTROENTEROLOGY, 2013, 145 (02) :375-+

[7] Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis [J].

Athyros, Vasilios G. ;

Tziomalos, Konstantinos ;

Gossios, Thomas D. ;

Griva, Theodora ;

Anagnostis, Panagiotis ;

Kargiotis, Konstantinos ;

Pagourelias, Efstathios D. ;

Theocharidou, Eleni ;

Karagiannis, Asterios ;

Mikhailidis, Dimitri P. .

LANCET, 2010, 376 (9756) :1916-1922

[8] Cigarette Smoking Exacerbates Nonalcoholic Fatty Liver Disease in Obese Rats [J].

Azzalini, Lorenzo ;

Ferrer, Elisabet ;

Ramalho, Leandra N. ;

Moreno, Montserrat ;

Dominguez, Marlene ;

Colmenero, Jordi ;

Peinado, Victor I. ;

Barbera, Joan A. ;

Arroyo, Vicente ;

Gines, Pere ;

Caballeria, Joan ;

Bataller, Ramon .

HEPATOLOGY, 2010, 51 (05) :1567-1576

[9] Hepatocellular carcinoma in non-alcoholic fatty liver disease: An emerging menace [J].

Baffy, Gyoergy ;

Brunt, Elizabeth M. ;

Caldwell, Stephen H. .

JOURNAL OF HEPATOLOGY, 2012, 56 (06) :1384-1391

[10] Rifaximin Treatment in Hepatic Encephalopathy [J].

Bass, Nathan M. ;

Mullen, Kevin D. ;

Sanyal, Arun ;

Poordad, Fred ;

Neff, Guy ;

Leevy, Carroll B. ;

Sigal, Samuel ;

Sheikh, Muhammad Y. ;

Beavers, Kimberly ;

Frederick, Todd ;

Teperman, Lewis ;

Hillebrand, Donald ;

Huang, Shirley ;

Merchant, Kunal ;

Shaw, Audrey ;

Bortey, Enoch ;

Forbes, William P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (12) :1071-1081

← 1 2 3 4 5 6 7 8 9 10 →