Anti-Mullerian Hormone in PCOS: A Review Informing International Guidelines

被引：135

作者：

Teede, Helena ^{[1
,2
]}

Misso, Marie ^{[1
,2
]}

Tassone, Eliza C. ^{[1
,2
]}

Dewailly, Didier ^{[3
]}

Ng, Ernest Hy ^{[4
]}

Azziz, Ricardo ^{[5
]}

Norman, Robert J. ^{[6
,7
]}

Andersen, Marianne ^{[8
]}

Franks, Stephen ^{[9
]}

Hoeger, Kathleen ^{[10
]}

Hutchison, Samantha ^{[11
,12
]}

Oberfield, Sharon ^{[13
]}

Shah, Duru ^{[14
]}

Hohmann, Femke ^{[15
]}

Ottey, Sasha ^{[16
]}

Dabadghao, Preeti ^{[17
]}

Laven, Joop S. E. ^{[18
]}

机构：

[1] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Locked Bag 29, Clayton, Vic 3168, Australia

[2] Monash Hlth, Locked Bag 29, Clayton, Vic 3168, Australia

[3] Univ Lille, Fac Med, Lille, France

[4] Univ Hong Kong, Dept Obstet & Gynaecol, Li Ka Shing Fac Med, Hong Kong, Peoples R China

[5] SUNY Albany, Sch Publ Hlth, Dept Hlth Policy Management & Behav, Albany, NY 12144 USA

[6] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia

[7] Fertility SA, Adelaide, SA, Australia

[8] Univ Southern Denmark, Odense Univ Hosp, Dept Endocrinol, Clin Inst, DK-5000 Odense C, Denmark

[9] Imperial Coll London, Hammersmith Hosp, Inst Reprod & Dev Biol, London W12 0NN, England

[10] Univ Rochester, Dept Obstet & Gynecol, Div Reprod Endocrinol, 601 Elmwood Ave, Rochester, NY 14642 USA

[11] Monash Hlth, Diabet Unit, Clayton, Vic 3168, Australia

[12] Monash Hlth, Endocrine Unit, Clayton, Vic 3168, Australia

[13] Columbia Univ, Med Ctr, Dept Pediat, Div Endocrinol Diabet & Metab, New York, NY 10032 USA

[14] Gynaecworld, Ctr Womens Hlth & Fertil, Mumbai 400036, Maharashtra, India

[15] Huisartsenpraktijk Hohmann & De Vet, NL-3061 Rotterdam, Netherlands

[16] PCOS Challenge Inc, 931 Monroe Dr NE,Suite A-470, Atlanta, GA 30308 USA

[17] Sanjay Gandhi Postgrad Inst Med Sci, Dept Endocrinol, Raebareli Rd, Lucknow 226014, Uttar Pradesh, India

[18] Univ Med Ctr, Erasmus MC, Dept Obstet & Gynecol, Div Reprod Med, Rotterdam, Netherlands

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2019年 / 30卷 / 07期

基金：

英国医学研究理事会;

关键词：

POLYCYSTIC-OVARY-SYNDROME; INHIBITING SUBSTANCE; DIAGNOSTIC MARKER; ADOLESCENT GIRLS; FOLLICLE COUNT; SERUM-LEVELS; WOMEN; AMH; PREVALENCE; ULTRASOUND;

D O I：

10.1016/j.tem.2019.04.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Polycystic ovary syndrome (PCOS) affects 8-13% of women. The Rotterdam diagnostic criteria include polycystic ovarian morphology (PCOM) on ultrasound, but given recognized challenges, serum anti-Mullerian hormone (AMH) is proposed as an alternative. To inform international PCOS guidelines, a systematic review was completed. Key identified gaps include large international studies in well-defined populations across the lifespan, clustering of AMH with PCOS features, relationships to long-term health outcomes, and improved quality, assay standardization, and sample handling, all needed to determine cut offs. Here we identify research priorities to address these gaps and enhance AMH utility in PCOS. Once issues are addressed, AMH levels could replace more costly and less accessible ultrasound in PCOS diagnosis.

引用

页码：467 / 478

页数：12

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