The role of matrix in HIV-1 envelope glycoprotein incorporation

被引：56

作者：

Tedbury, Philip R. ^{[1
]}

Freed, Eric O. ^{[1
]}

机构：

[1] NCI, Virus Cell Interact Sect, HIV Drug Resistance Program, Ctr Canc Res, Frederick, MD 21702 USA

来源：

TRENDS IN MICROBIOLOGY | 2014年 / 22卷 / 07期

基金：

美国国家卫生研究院;

关键词：

HIV-1; matrix; envelope; assembly; packaging; VIRUS TYPE-1 MATRIX; GP41 CYTOPLASMIC TAIL; MURINE LEUKEMIA-VIRUS; PLASMA-MEMBRANE; RETROVIRAL VECTOR; ENV INCORPORATION; ASSEMBLY SITES; GAG-PROTEINS; MYOSIN VB; IMMUNODEFICIENCY;

D O I：

10.1016/j.tim.2014.04.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Incorporation of the viral envelope (Env) glycoprotein is a critical requirement for the production of infectious HIV-1 particles. It has long been appreciated that the matrix (MA) domain of the Gag polyprotein and the cytoplasmic tail of Env are central players in the process of Env incorporation, but the precise mechanisms have been elusive. Several recent developments have thrown light on the contributions of both proteins, prompting a re-evaluation of the role of MA during Env incorporation. The two domains appear to play distinct but complementary roles, with the cytoplasmic tail of Env responsible for directing Env to the site of assembly and the matrix domain accommodating the cytoplasmic tail of Env in the Gag lattice.

引用

页码：372 / 378

页数：7

共 53 条

[11] The frantic play of the concealed HIV envelope cytoplasmic tail [J].

da Silva, Eveline Santos ;

Mulinge, Martin ;

Bercoff, Danielle Perez .

RETROVIROLOGY, 2013, 10

[12] Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis [J].

Fan, GH ;

Lapierre, LA ;

Goldenring, JR ;

Sai, JQ ;

Richmond, A .

MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (05) :2456-2469

[13]

Freed E.O., 2013, FIELDS VIROLOGY, V6th, P1502

[14] VIRION INCORPORATION OF ENVELOPE GLYCOPROTEINS WITH LONG BUT NOT SHORT CYTOPLASMIC TAILS IS BLOCKED BY SPECIFIC, SINGLE AMINO-ACID SUBSTITUTIONS IN THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 MATRIX [J].

FREED, EO ;

MARTIN, MA .

JOURNAL OF VIROLOGY, 1995, 69 (03) :1984-1989

[15] SINGLE AMINO-ACID CHANGES IN THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 MATRIX PROTEIN BLOCK VIRUS PARTICLE-PRODUCTION [J].

FREED, EO ;

ORENSTEIN, JM ;

BUCKLERWHITE, AJ ;

MARTIN, MA .

JOURNAL OF VIROLOGY, 1994, 68 (08) :5311-5320

[16] Domains of the human immunodeficiency virus type 1 matrix and gp41 cytoplasmic tail required for envelope incorporation into virions [J].

Freed, EO ;

Martin, MA .

JOURNAL OF VIROLOGY, 1996, 70 (01) :341-351

[17] Multiple Gag Domains Contribute to Selective Recruitment of Murine Leukemia Virus (MLV) Env to MLV Virions [J].

Gregory, Devon A. ;

Lyddon, Terri D. ;

Johnson, Marc C. .

JOURNAL OF VIROLOGY, 2013, 87 (03) :1518-1527

[18] Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: Implications for membrane association and assembly [J].

Hill, CP ;

Worthylake, D ;

Bancroft, DP ;

Christensen, AM ;

Sundquist, WI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (07) :3099-3104

[19] Truncation of the human immunodeficiency virus-type-2 envelope glycoprotein allows efficient pseudotyping of murine leukemia virus retroviral vector particles [J].

Höhne, M ;

Thaler, S ;

Dudda, JC ;

Groner, B ;

Schnierle, BS .

VIROLOGY, 1999, 261 (01) :70-78

[20] Assembly of human immunodeficiency virus precursor Gag proteins [J].

Huseby, D ;

Barklis, RL ;

Alfadhli, A ;

Barklis, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (18) :17664-17670

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