Case numbers for a randomized clinical trial of boron neutron capture therapy for Glioblastoma multiforme

被引：8

作者：

Sander, Anja ^{[1
,3
]}

Wosniok, Werner ^{[1
,3
]}

Gabel, Detlef ^{[2
,3
,4
]}

机构：

[1] Kompetenzzentrum Klin Studien KKS, Bremen, Germany

[2] Univ Bremen, Dept Chem, D-28359 Bremen, Germany

[3] Univ Bremen, Cooperat Ctr Med, D-28359 Bremen, Germany

[4] Jacobs Univ Bremen, Sch Sci & Engn, D-28759 Bremen, Germany

来源：

APPLIED RADIATION AND ISOTOPES | 2014年 / 88卷

关键词：

BNCT; BSH; BPA; Glioblastoma; Design of clinical trials; PHASE-II; BORONOPHENYLALANINE;

D O I：

10.1016/j.apradiso.2013.11.092

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Boron neutron capture therapy (BNCT) with Na2B12H11SH (BSH) or p-dihydroxyborylphenylalanine (BPA), and with a combination of both, was compared to radiotherapy with temozolomide, and the number of patients required to show statistically significant differences between the treatments was calculated. Whereas arms using BPA require excessive number of patients in each arm, a two-armed clinical trial with BSH and radiotherapy plus temozolomide is feasible. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：16 / 19

页数：4

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