Total synthesis of (-)-callystatin A

被引：73
|
作者：
Marshall, JA [1 ]
Bourbeau, MP [1 ]
机构：
[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2002年 / 67卷 / 09期
关键词：
D O I：
10.1021/jo016025d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A total synthesis of the cytotoxic polyketide marine natural product callystatin A is described. The route features chiral allenylmetal additions to construct the polypropionate C15-22 segment and an sp(2)-sp(3) Suzuki coupling to join the C1-C11 and C12-C22 subunits.
引用
收藏
页码：2751 / 2754
页数：4
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