Tardive dyskinesia: Possible involvement of free radicals and treatment with vitamin E

被引：83
|
作者：
Elkashef, AM
Wyatt, RJ
机构：
[1] NIDA, Medicat Dev Div, Bethesda, MD 20892 USA
[2] NIDA, Neuropsychiat Branch, NIH, Bethesda, MD 20892 USA
来源：
SCHIZOPHRENIA BULLETIN | 1999年 / 25卷 / 04期
关键词：
tardive dyskinesia; free radicals; neurodegeneration; vitamin E; antioxidants; neuroleptic;
D O I：
10.1093/oxfordjournals.schbul.a033414
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
A decade ago a hypothesis introduced to explain tardive dyskinesia (TD) implicated free radicals generated secondary to neuroleptic treatment. Since then many preclinical and clinical studies have investigated this possibility. These studies suggest that free radicals are probably involved in the pathogenesis of TD and that vitamin E could be efficacious in its treatment.
引用
收藏
页码：731 / 740
页数：10
相关论文
共 50 条
  • [1] VITAMIN-E IN THE TREATMENT OF TARDIVE-DYSKINESIA - THE POSSIBLE INVOLVEMENT OF FREE-RADICAL MECHANISMS
    LOHR, JB
    CADET, JL
    LOHR, MA
    LARSON, L
    WASLI, E
    WADE, L
    HYLTON, R
    VIDONI, C
    JESTE, DV
    WYATT, RJ
    SCHIZOPHRENIA BULLETIN, 1988, 14 (02) : 291 - 296
  • [2] POSSIBLE INVOLVEMENT OF FREE-RADICALS IN NEUROLEPTIC-INDUCED MOVEMENT-DISORDERS - EVIDENCE FROM TREATMENT OF TARDIVE-DYSKINESIA WITH VITAMIN-E
    CADET, JL
    LOHR, JB
    VITAMIN E : BIOCHEMISTRY AND HEALTH IMPLICATIONS, 1989, 570 : 176 - 185
  • [3] POSSIBLE INVOLVEMENT OF FREE-RADICALS IN NEUROLEPTIC-INDUCED MOVEMENT-DISORDERS - EVIDENCE FROM TREATMENT OF TARDIVE-DYSKINESIA WITH VITAMIN-E
    CADET, JL
    LOHR, JB
    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1989, 570 : 176 - 185
  • [4] Vitamin E in the treatment of tardive dyskinesia
    Boomershine, KH
    Shelton, PS
    Boomershine, JE
    ANNALS OF PHARMACOTHERAPY, 1999, 33 (11) : 1195 - 1202
  • [5] Treatment of tardive dyskinesia with vitamin E
    Shteinlukht, TP
    BIOLOGICAL PSYCHIATRY, 2006, 59 (08) : 259S - 260S
  • [6] Vitamin E treatment for tardive dyskinesia
    Adler, LA
    Rotrosen, J
    Edson, R
    Lavori, P
    Lohr, J
    Hitzemann, R
    Raisch, D
    Caligiuri, M
    Tracy, K
    ARCHIVES OF GENERAL PSYCHIATRY, 1999, 56 (09) : 836 - 841
  • [7] Vitamin E treatment in tardive dyskinesia
    Dannon, PN
    Lepkifker, E
    Iancu, I
    Ziv, R
    Horesh, N
    Kotler, M
    HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 1997, 12 (03) : 217 - 220
  • [8] VITAMIN-E IN THE TREATMENT OF TARDIVE-DYSKINESIA
    ELKASHEF, AM
    RUSKIN, PE
    BACHER, N
    BARRETT, D
    AMERICAN JOURNAL OF PSYCHIATRY, 1990, 147 (04): : 505 - 506
  • [9] VITAMIN-E TREATMENT OF TARDIVE-DYSKINESIA
    ADLER, LA
    PESELOW, E
    ROTROSEN, J
    DUNCAN, E
    LEE, M
    ROSENTHAL, M
    ANGRIST, B
    AMERICAN JOURNAL OF PSYCHIATRY, 1993, 150 (09): : 1405 - 1407
  • [10] VITAMIN-E TREATMENT OF TARDIVE-DYSKINESIA
    CORRIGAN, FM
    VANRHIJN, AG
    MACKAY, AVP
    SKINNER, ER
    HORROBIN, DF
    AMERICAN JOURNAL OF PSYCHIATRY, 1993, 150 (06): : 991 - 992
12345