Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2-Specific Immune Responses

被引：12

作者：

Kim, Kyun-Do ^{[1
]}

Hwang, Insu ^{[1
]}

Ku, Keun Bon ^{[1
]}

Lee, Sumin ^{[1
]}

Kim, Seong-Jun ^{[1
]}

Kim, Chonsaeng ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Ctr Convergent Res Emerging Virus Infect, Daejeon 34114, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2020年 / 30卷 / 08期

关键词：

COVID-19; SARS-CoV-2; Coronavirus; vaccine; immune response; RESPIRATORY-SYNDROME-CORONAVIRUS; NEUTRALIZING ANTIBODIES; INFLAMMATORY CYTOKINES; SARS; ACTIVATION; RECEPTORS; INFECTION; SPIKE; INTERFERON; EXPRESSION;

D O I：

10.4014/jmb.2006.06006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading globally, and the WHO has declared this outbreak a pandemic. Vaccines are an effective way to prevent the rapid spread of COVID-19. Furthermore, the immune response against SARS-CoV-2 infection needs to be understood for the development of an efficient and safe vaccine. Here, we review the current understanding of vaccine targets and the status of vaccine development for COVID-19. We also describe host immune responses to highly pathogenic human coronaviruses in terms of innate and adaptive immunities.

引用

页码：1109 / 1115

页数：7

共 69 条

[11] Cucinotta Domenico, 2020, Acta Biomed, V91, P157, DOI 10.23750/abm.v91i1.9397
[12] COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics
Dhama, Kuldeep
Sharun, Khan
Tiwari, Ruchi
Dadar, Maryam
Malik, Yashpal Singh
Singh, Karam Pal
Chaicumpa, Wanpen
[J]. HUMAN VACCINES & IMMUNOTHERAPEUTICS, 2020, 16 (06) : 1232 - 1238
[13] Molecular pathology of emerging coronavirus infections
Gralinski, Lisa E.
Baric, Ralph S.
[J]. JOURNAL OF PATHOLOGY, 2015, 235 (02) : 185 - 195
[14] Clinical Characteristics of Coronavirus Disease 2019 in China
Guan, W.
Ni, Z.
Hu, Yu
Liang, W.
Ou, C.
He, J.
Liu, L.
Shan, H.
Lei, C.
Hui, D. S. C.
Du, B.
Li, L.
Zeng, G.
Yuen, K. -Y.
Chen, R.
Tang, C.
Wang, T.
Chen, P.
Xiang, J.
Li, S.
Wang, Jin-lin
Liang, Z.
Peng, Y.
Wei, L.
Liu, Y.
Hu, Ya-hua
Peng, P.
Wang, Jian-ming
Liu, J.
Chen, Z.
Li, G.
Zheng, Z.
Qiu, S.
Luo, J.
Ye, C.
Zhu, S.
Zhong, N.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (18) : 1708 - 1720
[15] Interferon-induced mx proteins: Dynamin-like GTPases with antiviral activity
Haller, O
Kochs, G
[J]. TRAFFIC, 2002, 3 (10) : 710 - 717
[16] Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020
Haveri, Anu
Smura, Teemu
Kuivanen, Suvi
Osterlund, Pamela
Hepojoki, Jussi
Ikonen, Niina
Pitkapaasi, Marjaana
Blomqvist, Soile
Ronkko, Esa
Kantele, Anu
Strandin, Tomas
Kallio-Kokko, Hannimari
Mannonen, Laura
Lappalainen, Maija
Broas, Markku
Jiang, Miao
Siira, Lotta
Salminen, Mika
Puumalainen, Taneli
Sane, Jussi
Melin, Merit
Vapalahti, Olli
Savolainen-Kopra, Carita
[J]. EUROSURVEILLANCE, 2020, 25 (11) : 16 - 21
[17] Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients:: relation to the acute lung injury and pathogenesis of SARS
He, L.
Ding, Y.
Zhang, Q.
Che, X.
He, Y.
Shen, H.
Wang, H.
Li, Z.
Zhao, L.
Geng, J.
Deng, Y.
Yang, L.
Li, J.
Cai, J.
Qiu, L.
Wen, K.
Xu, X.
Jiang, S.
[J]. JOURNAL OF PATHOLOGY, 2006, 210 (03) : 288 - 297
[18] Huang CL, 2020, LANCET, V395, P497, DOI [10.1016/S0140-6736(20)30183-5, 10.1016/S0140-6736(20)30211-7]
[19] Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion
Jensen, Soren
Thomsen, Allan Randrup
[J]. JOURNAL OF VIROLOGY, 2012, 86 (06) : 2900 - 2910
[20] SARS vaccine development
Jiang, SB
He, YX
Liu, SW
[J]. EMERGING INFECTIOUS DISEASES, 2005, 11 (07) : 1016 - 1020

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