Unmet need in rheumatology: reports from the Targeted Therapies meeting 2018

被引：20

作者：

Winthrop, Kevin L. ^{[1
]}

Weinblatt, Michael E. ^{[2
]}

Crow, Mary K. ^{[3
]}

Burmester, Gerd R. ^{[4
]}

Mease, Philip J. ^{[5
]}

So, Alexander K. ^{[6
]}

Bykerk, Vivian ^{[3
]}

Van Vollenhoven, Ronald F. ^{[7
]}

Dougados, Maxime ^{[8
]}

Kay, Jonathan ^{[9
]}

Mariette, Xavier ^{[10
]}

Sieper, Joachim ^{[11
]}

Melchers, Fritz ^{[12
,13
]}

Cronstein, Bruce N. ^{[14
]}

Shevach, Ethan ^{[15
]}

Breedfeld, Ferdinand C. ^{[16
]}

Kalden, Joachim ^{[17
]}

Smolen, Josef S. ^{[18
]}

Furst, Daniel E. ^{[5
,19
,20
]}

机构：

[1] Oregon Hlth & Sci Univ, Portland, OR 97239 USA

[2] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

[3] Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA

[4] Charite Univ Med Berlin, Berlin, Germany

[5] Univ Washington, Swedish Med Ctr, Seattle, WA 98195 USA

[6] Univ Lausanne, Lausanne, Switzerland

[7] Amsterdam Rheumatol & Immunol Ctr, Amsterdam, Netherlands

[8] Hop Cochin, Paris, France

[9] Univ Massachusetts, Med Sch, Worcester, MA 01605 USA

[10] Paris Sud Univ, Orsay, France

[11] Charite, Campus Benjamin Franklin, Dept Gastroenterol Infect Dis & Rheumatol, Berlin, Germany

[12] Max Planck Inst Infect Biol, Berlin, Germany

[13] Deutsch Rheumaforschungszentrum, Berlin, Germany

[14] NYU, Sch Med, New York, NY USA

[15] NIH, Bldg 10, Bethesda, MD 20892 USA

[16] Leiden Univ, Med Ctr, Leiden, Netherlands

[17] Univ Erlangen Nurnberg, Erlangen, Germany

[18] Med Univ Vienna, Dept Med 3, Div Rheumatol, Vienna, Austria

[19] Univ Calif Los Angeles, Los Angeles Med Ctr, Los Angeles, CA USA

[20] Univ Florence, Florence, Italy

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2019年 / 78卷 / 07期

关键词：

PSORIATIC-ARTHRITIS; EULAR RECOMMENDATIONS; MANAGEMENT; DERMATOLOGY; DISEASE; COMORBIDITIES; PREDICTORS; EFFICACY; IMPACT; DRUGS;

D O I：

10.1136/annrheumdis-2018-214280

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To develop a comprehensive listing of the greatest unmet scientific and clinical needs in rheumatology. The 20th annual international Targeted Therapies meeting brought more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of five disease-specific groups with 20-30 experts assigned to each group based on expertise. Specific groups included rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus, connective tissue diseases and a basic science immunology group spanning all of these clinical domains. In each group, experts were asked to consider recent accomplishments within their clinical domain in the last year and update the unmet needs in three categorical areas: basic/translational science, clinical science and therapeutic development, and clinical care. While progress was noted among some of previously identified needs, both new needs were identified and themes from prior meetings were re-iterated: the need for better understanding the heterogeneity within each disease, and for identifying preclinical states of disease allowing treatment and prevention of disease in those at risk, and the elusive ability to cure disease. Within the clinical care realm, improved comorbidity management and patient-centred care continue to be unmet needs, and the need for new and affordable therapeutics was highlighted. Unmet needs for new and accessible targeted therapies, disease prevention and ultimately cure remain a priority in rheumatology.

引用

页码：872 / 878

页数：7

共 60 条

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