Potential therapeutic effects of functionally active compounds isolated from garlic

被引：107

作者：

Yun, Hyung-Mun ^{[1
,2
]}

Ban, Jung Ok ^{[1
,2
]}

Park, Kyung-Ran ^{[1
,2
]}

Lee, Chong Kil ^{[1
,2
]}

Jeong, Heon-Sang ^{[3
]}

Han, Sang Bae ^{[1
,2
]}

Hong, Jin Tae ^{[1
,2
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, Chungbuk, South Korea

[2] Chungbuk Natl Univ, Med Res Ctr, Cheongju 361763, Chungbuk, South Korea

[3] Chungbuk Natl Univ, Dept Food Sci & Technol, Chungbuk 361763, South Korea

来源：

PHARMACOLOGY & THERAPEUTICS | 2014年 / 142卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Garlic; Organosulfur compounds; Cancer; Cardiovascular disorders; Neurological diseases; Liver diseases; Allergy; Arthritis; ALLERGIC CONTACT-DERMATITIS; INDUCED OXIDATIVE STRESS; PROSTATE-CANCER CELLS; NITRIC-OXIDE SYNTHASE; ALLIUM-SATIVUM L; DIALLYL TRISULFIDE; PLATELET-AGGREGATION; GASTRIC-CANCER; IN-VIVO; ORGANOSULFUR COMPOUNDS;

D O I：

10.1016/j.pharmthera.2013.12.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The medicinal properties of functionally active organosulfur compounds such as allin, diallyl disulfide, S-allylmercaptocysteine, and S-trityl-L-cysteine isolated from garlic have received great attention from a large number of investigators who have studied their pharmacological effects for the treatment of various diseases. These organosulfur compounds are able to prevent for development of cancer, cardiovascular, neurological, and liver diseases as well as allergy and arthritis. There have been also many reports on toxicities and pharmacokinetics of these compounds. The aim of this study is to review a variety of experimental and clinical reports, and describe the effectiveness, toxicities and pharmacokinetics, and possible mechanisms of pharmaceutical actions of functionally active compounds isolated from garlic. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：183 / 195

页数：13

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