Peripheral neuropathy in ART-experienced patients: prevalence and risk factors

被引：42

作者：

Chen, Huichao ^{[1
]}

Clifford, David B. ^{[2
]}

Deng, Lijuan ^{[1
]}

Wu, Kunling ^{[1
]}

Lee, Anthony J. ^{[1
]}

Bosch, Ronald J. ^{[1
]}

Riddler, Sharon A. ^{[3
]}

Ellis, Ronald J. ^{[4
]}

Evans, Scott R. ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[2] Washington Univ, St Louis, MO USA

[3] Univ Pittsburgh, Pittsburgh, PA USA

[4] Univ Calif San Diego, San Diego, CA 92103 USA

来源：

JOURNAL OF NEUROVIROLOGY | 2013年 / 19卷 / 06期

关键词：

Peripheral neuropathy; Symptomatic peripheral neuropathy; Risk factors; HIV infection; ENHANCED PROTEASE INHIBITORS; SENSORY NEUROPATHY; RANDOMIZED-TRIAL; CCR5; INHIBITOR; HIV NEUROPATHY; AIDS; THERAPY; ASSOCIATION; INFECTION; DISEASE;

D O I：

10.1007/s13365-013-0216-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peripheral neuropathy (PN) is a common neurological complication of HIV infection that has debilitating effects on quality of life. While there has been a comprehensive evaluation of the prevalence of neuropathic signs/symptoms and risk factors (RFs) for PN or symptomatic PN (SPN) with initiation of combination antiretroviral therapy (cART) in ART-naive patients, similar evaluation in ART-experienced patients is limited. This study investigated the prevalence and RFs for PN/SPN in ART-experienced patients enrolled in clinical salvage therapy studies. Between February 2000 and June 2007, 522 ART-experienced participants who experienced virologic failure with a prior regimen and started new regimens were followed longitudinally and annually screened for signs and symptoms of PN. Rates of PN/SPN at 3 years since parent study entry were 52.8 and 24.0 %, respectively. Aging, taller height, protease inhibitor use, and female sex were significant RFs for PN/SPN. The use of statin drugs was significantly associated with lower odds of SPN, and it may prevent progression from no SPN to SPN.

引用

页码：557 / 564

页数：8

共 34 条

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