Peripheral neuropathy in ART-experienced patients: prevalence and risk factors

被引：42

作者：

Chen, Huichao ^{[1
]}

Clifford, David B. ^{[2
]}

Deng, Lijuan ^{[1
]}

Wu, Kunling ^{[1
]}

Lee, Anthony J. ^{[1
]}

Bosch, Ronald J. ^{[1
]}

Riddler, Sharon A. ^{[3
]}

Ellis, Ronald J. ^{[4
]}

Evans, Scott R. ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[2] Washington Univ, St Louis, MO USA

[3] Univ Pittsburgh, Pittsburgh, PA USA

[4] Univ Calif San Diego, San Diego, CA 92103 USA

来源：

JOURNAL OF NEUROVIROLOGY | 2013年 / 19卷 / 06期

关键词：

Peripheral neuropathy; Symptomatic peripheral neuropathy; Risk factors; HIV infection; ENHANCED PROTEASE INHIBITORS; SENSORY NEUROPATHY; RANDOMIZED-TRIAL; CCR5; INHIBITOR; HIV NEUROPATHY; AIDS; THERAPY; ASSOCIATION; INFECTION; DISEASE;

D O I：

10.1007/s13365-013-0216-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Peripheral neuropathy (PN) is a common neurological complication of HIV infection that has debilitating effects on quality of life. While there has been a comprehensive evaluation of the prevalence of neuropathic signs/symptoms and risk factors (RFs) for PN or symptomatic PN (SPN) with initiation of combination antiretroviral therapy (cART) in ART-naive patients, similar evaluation in ART-experienced patients is limited. This study investigated the prevalence and RFs for PN/SPN in ART-experienced patients enrolled in clinical salvage therapy studies. Between February 2000 and June 2007, 522 ART-experienced participants who experienced virologic failure with a prior regimen and started new regimens were followed longitudinally and annually screened for signs and symptoms of PN. Rates of PN/SPN at 3 years since parent study entry were 52.8 and 24.0 %, respectively. Aging, taller height, protease inhibitor use, and female sex were significant RFs for PN/SPN. The use of statin drugs was significantly associated with lower odds of SPN, and it may prevent progression from no SPN to SPN.

引用

页码：557 / 564

页数：8

共 34 条

[1] TEMPORAL TRENDS IN THE INCIDENCE OF HTV-1-RELATED NEUROLOGIC DISEASES - MULTICENTER AIDS COHORT STUDY, 1985-1992 [J].

BACELLAR, H ;

MUNOZ, A ;

MILLER, EN ;

COHEN, BA ;

BESLEY, D ;

SELNES, OA ;

BECKER, JT ;

MCARTHUR, JC .

NEUROLOGY, 1994, 44 (10) :1892-1900

[2] Hypertriglyceridemia in combination antiretroviral-treated HIV-positive individuals: potential impact on HIV sensory polyneuropathy [J].

Banerjee, Sugato ;

McCutchan, J. Allen ;

Ances, Beau M. ;

Deutsch, Reena ;

Riggs, Patricia K. ;

Way, Lauren ;

Ellis, Ronald J. .

AIDS, 2011, 25 (02) :F1-F6

[3] Effects of active HCV replication on neurologic status in HIV RNA virally suppressed patients [J].

Clifford, D. B. ;

Smurzynski, M. ;

Park, L. S. ;

Yeh, T. -M. ;

Zhao, Y. ;

Blair, L. ;

Arens, M. ;

Evans, S. R. .

NEUROLOGY, 2009, 73 (04) :309-314

[4] Randomized study of dual versus single ritonavir-enhanced protease inhibitors for protease inhibitor-experienced patients with HIV [J].

Collier, Ann C. ;

Tierney, Camlin ;

Downey, Gerald F. ;

Eshleman, Susan H. ;

Kashuba, Angela ;

Klingman, Karin ;

Vergis, Emanuel N. ;

Pakes, Gary E. ;

Rooney, James F. ;

Rinehart, Alex ;

Mellors, John W. .

HIV CLINICAL TRIALS, 2008, 9 (02) :91-102

[5] PREDOMINANTLY SENSORY NEUROPATHY IN PATIENTS WITH AIDS AND AIDS-RELATED COMPLEX [J].

CORNBLATH, DR ;

MCARTHUR, JC .

NEUROLOGY, 1988, 38 (05) :794-796

[6]

Coulson WF, 2011, J FAM PRACTICE, V60, P182

[7] A randomized trial of therapeutic drug monitoring of protease inhibitors in antiretroviral-experienced, HIV-1-infected patients [J].

Demeter, Lisa M. ;

Jiang, Hongyu ;

Mukherjee, A. Lisa ;

Morse, Gene D. ;

DiFrancesco, Robin ;

DiCenzo, Robert ;

Dykes, Carrie ;

Sista, Prakash ;

Bacheler, Lee ;

Klingman, Karin ;

Rinehart, Alex ;

Albrecht, Mary .

AIDS, 2009, 23 (03) :357-368

[8] Clinical validation of the NeuroScreen [J].

Ellis, RJ ;

Evans, SR ;

Clifford, DB ;

Moo, LR ;

McArthur, JC ;

Collier, AC ;

Benson, C ;

Bosch, R ;

Simpson, D ;

Yiannoutsos, CT ;

Yang, YJ ;

Robertson, K .

JOURNAL OF NEUROVIROLOGY, 2005, 11 (06) :503-511

[9] Continued High Prevalence and Adverse Clinical Impact of Human Immunodeficiency Virus-Associated Sensory Neuropathy in the Era of Combination Antiretroviral Therapy The CHARTER Study [J].

Ellis, Ronald J. ;

Rosario, Debralee ;

Clifford, David B. ;

McArthur, Justin C. ;

Simpson, David ;

Alexander, Terry ;

Gelman, Benjamin B. ;

Vaida, Florin ;

Collier, Ann ;

Marra, Christina M. ;

Ances, Beau ;

Atkinson, J. Hampton ;

Dworkin, Robert H. ;

Morgello, Susan ;

Grant, Igor .

ARCHIVES OF NEUROLOGY, 2010, 67 (05) :552-558

[10] Human Immunodeficiency Virus Protease Inhibitors and Risk for Peripheral Neuropathy [J].

Ellis, Ronald J. ;

Marquie-Beck, Jennifer ;

Delaney, Patrick ;

Alexander, Terry ;

Clifford, David B. ;

McArthur, Justin C. ;

Simpson, David M. ;

Ake, Christopher ;

Collier, Ann C. ;

Gelman, Benjamin B. ;

McCutchan, J. Allen ;

Morgello, Susan ;

Grant, Igor .

ANNALS OF NEUROLOGY, 2008, 64 (05) :566-572

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