Microstructure of the non-rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: Effects of Dopaminergic treatment

被引：72

作者：

Brunner, H ^{[1
]}

Wetter, TC ^{[1
]}

Hoegl, B ^{[1
]}

Yassouridis, A ^{[1
]}

Trenkwalder, C ^{[1
]}

Friess, E ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

MOVEMENT DISORDERS | 2002年 / 17卷 / 05期

关键词：

Parkinson's disease; quantitative EEG; EEG power spectrum; non-REM sleep; delta power; dopamine;

D O I：

10.1002/mds.10242

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated non-rapid eye movement (non-REM) sleep in patients with newly diagnosed Parkinson's disease (PD) who had never previously received dopaminergic medication. There were no significant differences in the conventional sleep parameters between de novo patients with PD and a healthy control group, but the length of stage I sleep and the number of awakenings increased significantly upon administration of dopaminergic drugs. Analyzing the quantitative electroencephalogram (EEG), we observed a significant reduction in the low-delta frequency range and a nonsignificant increase in the sigma frequency range in de novo patients with PD. The dopaminergic medication also nonsignificantly reduced the low-delta and sigma frequencies, the latter to the level of the controls. Possible mechanisms that may account for the observed differences are discussed. It is suggested that Parkinson's disease as well as the application of dopaminergic drugs exerts a desynchronizing effect on the sleep EEG that is reflected in a disruption of sleep continuity. (C) 2002 Movement Disorder Society.

引用

页码：928 / 933

页数：6

共 33 条

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