Clostridium difficile in wild rodents and insectivores in the Netherlands

被引:11
作者
Krijger, I. M. [1 ,2 ]
Meerburg, B. G. [1 ,3 ]
Harmanus, C. [4 ]
Burt, S. A. [5 ]
机构
[1] Wageningen Univ & Res, Livestock Res, POB 338, NL-6700 AH Wageningen, Netherlands
[2] Wageningen Univ, Farm Technol Grp, Wageningen, Netherlands
[3] Dutch Pest & Wildlife Expertise Ctr KAD, Wageningen, Netherlands
[4] Leiden Univ, Med Ctr, Leiden, Netherlands
[5] Univ Utrecht, Div Environm Epidemiol & Vet Publ Hlth, Inst Risk Assessment Sci, Fac Vet Med, Utrecht, Netherlands
关键词
animal to human; Clostridioides difficile; farms; house mouse; Mus musculus; Rattus rattus; transmission; zoonotic pathogen; RATS RATTUS-NORVEGICUS; PCR RIBOTYPES; ANTIMICROBIAL SUSCEPTIBILITY; INFECTION; EPIDEMIOLOGY; PIGS; PREVALENCE; ANIMALS; ONTARIO; HUMANS;
D O I
10.1111/lam.13159
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
With wild rodents and insectivores being present around humans and their living, working and food production environments, it is important to gain knowledge of the zoonotic pathogens present in these animals. The enteropathogen Clostridium difficile, an opportunistic anaerobic bacteria, can be carried by both animals and humans, and is distributed globally. It is known that there is genetic overlap between human and animal sources of C. difficile. In this study, the aim was to assess the presence of C. difficile in rodents and insectivores trapped on and around pig and cattle farms in the Netherlands. In total 347 rodents and insectivores (10 different species) were trapped and 39 center dot 2% tested positive for presence of C. difficile. For all positive samples the ribotype (RT) was determined, and in total there were 13 different RTs found (in descending order of frequency: 057, 010, 029, 005, 073, 078, 015, 035, 454, 014, 058, 062, 087). Six of the RTs isolated from rodents and insectivores are known to be associated with human C. difficile infection; RT005, RT010, RT014, RT015, RT078 and RT087. The presence of rodents and insectivores in and around food production buildings (e.g. farms) could contribute to the spread of C. difficile in the human environment. In order to enable on-farm management for pathogen control, it is essential to comprehend the role of wild rodents and insectivores that could potentially affect the ecology of disease agents on farms.
引用
收藏
页码:35 / 40
页数:6
相关论文
共 49 条
  • [41] Rodents are a risk factor for the spreading of pathogens on farms
    Meerburg, B. G.
    [J]. VETERINARY MICROBIOLOGY, 2010, 142 (3-4) : 464 - 465
  • [42] Rodent-borne diseases and their risks for public health
    Meerburg, Bastiaan G.
    Singleton, Grant R.
    Kijlstra, Aize
    [J]. CRITICAL REVIEWS IN MICROBIOLOGY, 2009, 35 (03) : 221 - 270
  • [43] The zoonotic potential of Clostridium difficile from small companion animals and their owners
    Rabold, Denise
    Espelage, Werner
    Abu Sine, Muna
    Eckmanns, Tim
    Schneebereg, Alexander
    Neubauer, Heinrich
    Moebius, Nadine
    Hille, Katja
    Wieler, Lothar H.
    Seyboldt, Christian
    Luebke-Becker, Antina
    [J]. PLOS ONE, 2018, 13 (02):
  • [44] Seasonality of Clostridium difficile infections in Southern Germany
    Reil, M.
    Hensgens, M. P. M.
    Kuijper, E. J.
    Jakobiak, T.
    Gruber, H.
    Kist, M.
    Borgmann, S.
    [J]. EPIDEMIOLOGY AND INFECTION, 2012, 140 (10) : 1787 - 1793
  • [45] Rothenburger JL, 2018, CAN J VET RES, V82, P66
  • [46] Is Clostridium difficile-associated infection a potentially zoonotic and foodborne disease?
    Rupnik, M.
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 (05) : 457 - 459
  • [47] Clostridium difficile infection: new developments in epidemiology and pathogenesis
    Rupnik, Maja
    Wilcox, Mark H.
    Gerding, Dale N.
    [J]. NATURE REVIEWS MICROBIOLOGY, 2009, 7 (07) : 526 - 536
  • [48] Clostridium difficile in Retail Meat Products, USA, 2007
    Songer, J. Glenn
    Trinh, Hien T.
    Killgore, George E.
    Thompson, Angela D.
    McDonald, L. Clifford
    Limbago, Brandi M.
    [J]. EMERGING INFECTIOUS DISEASES, 2009, 15 (05) : 819 - 821
  • [49] Williams SH, 2018, MBIO, V9, DOI [10.1128/mBio.00624-18, 10.1128/mbio.00624-18]