Stochastic resonance algorithm for enhancement of signal-to-noise ratio of HPLC/MS signal

被引：0

作者：

Chen, Chang-Yun ^{[1
]}

Xie, Shao-Fei ^{[2
]}

Deng, Hai-Shan ^{[3
]}

Xiang, Bing-Ren ^{[3
]}

机构：

[1] Nanjing Xiaozhuang Univ, Dept Chem, Nanjing 211171, Jiangsu, Peoples R China

[2] Guangzhou Inst Drug Control, Guangzhou 510160, Guangdong, Peoples R China

[3] China Pharmaceut Univ, Ctr Instrumental Anal, Nanjing 210009, Jiangsu, Peoples R China

来源：

2010 4TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING (ICBBE 2010) | 2010年

关键词：

Stochastic resonance; Signal-to-noise ratio; HPLC/MS; Weak signal; Trace analysis;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Based on the theory of stochastic resonance, a new method was presented to enhance signal-to-noise ratio (SNR) of HPLC/MS signal for trace analysis with a new optimization method of the system parameters. The method was applied to experimental weak signals of HPLC/MS, which was embedded in the noise background and the SNR was enhanced greatly. The LOD and LOQ were improved from 10 ng/ml and 25 ng/ml to 2 ng/ml and 5 ng/ml, respectively. The results showed an excellent quantitative relationship between concentrations and chromatographic responses.

引用

页数：3

共 7 条

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