GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses

被引：348

作者：

Lo, Michael K. ^{[1
]}

Jordan, Robert ^{[2
]}

Arvey, Aaron ^{[2
]}

Sudhamsu, Jawahar ^{[2
]}

Shrivastava-Ranjan, Punya ^{[1
]}

Hotard, Anne L. ^{[1
]}

Flint, Mike ^{[1
]}

McMullan, Laura K. ^{[1
]}

Siegel, Dustin ^{[2
]}

Clarke, Michael O. ^{[2
]}

Mackman, Richard L. ^{[2
]}

Hui, Hon C. ^{[2
]}

Perron, Michel ^{[2
]}

Ray, Adrian S. ^{[2
]}

Cihlar, Tomas ^{[2
]}

Nichol, Stuart T. ^{[1
]}

Spiropoulou, Christina F. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Atlanta, GA 30329 USA

[2] Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

REVERSE GENETICS SYSTEM; FEVER VIRUS LACKING; ANTIVIRAL ACTIVITY; HIGH-THROUGHPUT; IN-VITRO; NIPAH VIRUSES; EBOLA-VIRUS; MODEL; PATHOGENESIS; POLYMERASE;

D O I：

10.1038/srep43395

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications for this compound against human viruses of significant public health concern.

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页数：7

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