Predictive markers for delayed lymph node metastases and survival in early-stage oral squamous cell carcinoma

被引:6
作者
Luksic, Ivica [1 ]
Suton, Petar [2 ]
机构
[1] Univ Zagreb, Sch Med, Univ Hosp Dubrava, Dept Maxillofacial Surg, Zagreb, Croatia
[2] Univ Hosp Tumors, Univ Hosp Ctr Sisters Mercy, Div Radiat Oncol, Dept Radiotherapy & Med Oncol, Zagreb, Croatia
来源
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 04期
关键词
oral cancer; delayed lymph node metastases; prognostic factors; recurrence; survival; LAMININ-5; GAMMA-2; CHAIN; PERINEURAL INVASION; NECK DISSECTION; MYOFIBROBLAST APPEARANCE; LYMPHOVASCULAR INVASION; DISTANT METASTASES; TUMOR THICKNESS; TONGUE; CANCER; FIBRONECTIN;
D O I
10.1002/hed.24667
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background. The purpose of this study was to identify clinicopathological and immunohistochemical factors predicting delayed lymph node metastases and survival in early oral squamous cell carcinoma (OSCC). Methods. The study included 85 consecutive patients with clinically T1 to T2N0 OSCC who were primarily surgically treated between 2000 and 2004. Results. There were 68 men and 17 women (median age, 61 years; range, 34-82 years). Of all the patients, 25 (29.4%) developed delayed lymph node metastases within 3 to 42 months after treatment of the primary tumor. Multivariate logistic regression analysis identified poorly differentiated tumors, low laminin, and high fibronectin expression as prognosticators of delayed lymph node metastases. Cox's proportional hazards regression analysis demonstrated that moderately differentiated tumors and delayed lymph node metastases had predictive value regarding survival. Conclusion. Large prospective investigations with reproducibility and the clinical translatability of immunohistochemical methods are needed in order to provide new and effective therapeutic strategies in the future. (C) 2016 Wiley Periodicals, Inc.
引用
收藏
页码:694 / 701
页数:8
相关论文
共 47 条
[1]   Predictive factors of occult metastasis and prognosis of clinical stages I and II squamous cell carcinoma of the tongue and floor of the mouth [J].
Amaral, TMP ;
da Silva Freire, AR ;
Carvalho, AL ;
Pinto, CAL ;
Kowalski, LP .
ORAL ONCOLOGY, 2004, 40 (08) :780-786
[2]  
AZNAVOORIAN S, 1993, CANCER-AM CANCER SOC, V71, P1368, DOI 10.1002/1097-0142(19930215)71:4<1368::AID-CNCR2820710432>3.0.CO
[3]  
2-L
[4]   Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer [J].
Bello, Ibrahim O. ;
Vered, Marilena ;
Dayan, Dan ;
Dobriyan, Alex ;
Yahalom, Ran ;
Alanen, Kalle ;
Nieminen, Pentti ;
Kantola, Saara ;
Laara, Esa ;
Salo, Tuula .
ORAL ONCOLOGY, 2011, 47 (01) :33-38
[5]   Fibrillary co-deposition of laminin-5 and large unspliced tenascin-C in the invasive front of oral squamous cell carcinoma in vivo and in vitro [J].
Berndt, A ;
Borsi, L ;
Hyckel, P ;
Kosmehl, H .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2001, 127 (05) :286-292
[6]   MALIGNANCY GRADING OF THE DEEP INVASIVE MARGINS OF ORAL SQUAMOUS-CELL CARCINOMAS HAS HIGH PROGNOSTIC VALUE [J].
BRYNE, M ;
KOPPANG, HS ;
LILLENG, R ;
KJAERHEIM, A .
JOURNAL OF PATHOLOGY, 1992, 166 (04) :375-381
[7]   Elective neck dissection in early-stage oral squamous cell carcinoma -: Does it influence recurrence and survival? [J].
Capote, Ana ;
Escorial, Veronica ;
Munoz-Guerra, Mario F. ;
Rodriguez-Campo, Francisco J. ;
Gamallo, Carlos ;
Naval, Luis .
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2007, 29 (01) :3-11
[8]   The Impact of Perineural Invasion and/or Lymphovascular Invasion on the Survival of Early-Stage Oral Squamous Cell Carcinoma Patients [J].
Chen, Tseng-Cheng ;
Wang, Cheng-Ping ;
Ko, Jeng-Yuh ;
Yang, Tsung-Lin ;
Hsu, Chun-Wei ;
Yeh, Kuo-An ;
Chang, Yih-Leong ;
Lou, Pei-Jen .
ANNALS OF SURGICAL ONCOLOGY, 2013, 20 (07) :2388-2395
[9]   Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer [J].
D'Cruz, Anil K. ;
Vaish, Richa ;
Kapre, Neeti ;
Dandekar, Mitali ;
Gupta, Sudeep ;
Hawaldar, Rohini ;
Agarwal, Jai Prakash ;
Pantvaidya, Gouri ;
Chaukar, Devendra ;
Deshmukh, Anuja ;
Kane, Shubhada ;
Arya, Supreeta ;
Ghosh-Laskar, Sarbani ;
Chaturvedi, Pankaj ;
Pai, Prathamesh ;
Nair, Sudhir ;
Nair, Deepa ;
Badwe, Rajendra .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (06) :521-529
[10]   Mesenchymal cells contribute to the synthesis and deposition of the laminin-5 γ2 chain in the invasive front of oral squamous cell carcinoma [J].
Franz, Marcus ;
Richter, Petra ;
Geyer, Christiane ;
Hansen, Torsten ;
Acuna, Lorena Dominguez ;
Hyckel, Peter ;
Boehmer, Frank D. ;
Kosmehl, Hartwig ;
Berndt, Alexander .
JOURNAL OF MOLECULAR HISTOLOGY, 2007, 38 (03) :183-190