A Purinergic Trail for Metastases

被引：25

作者：

Ferrari, Davide ^{[1
]}

Malavasi, Fabio ^{[2
,3
,4
]}

Antonioli, Luca ^{[5
]}

机构：

[1] Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy

[2] Univ Turin, Immunogenet Lab, Turin, Italy

[3] Univ Turin, CeRMS, Dept Med Sci, Turin, Italy

[4] Transplant Immunol Citta Salute & Sci, Turin, Italy

[5] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2017年 / 38卷 / 03期

关键词：

ADENOSINE-TRIPHOSPHATE ATP; P2X(7) RECEPTOR EXPRESSION; TUMOR-CELL INVASION; BREAST-CANCER CELLS; CARCINOMA-CELLS; EXTRACELLULAR NUCLEOTIDES; CHEMOKINE PRODUCTION; ENDOTHELIAL-CELLS; PROSTATE-CANCER; ACTIVATION;

D O I：

10.1016/j.tips.2016.11.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nucleotides and nucleosides have emerged as important modulators of tumor biology. Recently acquired evidence shows that, when these molecules are released by cancer cells or surrounding tissues, they act as potent prometastatic factors, favoring tumor cell migration and tissue colonization. Therefore, nucleotides and nucleosides should be considered as a new class of prometastatic factors. In this review, we focus on the prometastatic roles of nucleotides and discuss future applications of purinergic signaling modulation in view of antimetastatic therapies.

引用

页码：277 / 290

页数：14

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