Autoimmune Manifestations in Patients With Waldenstrom Macroglobulinemia

Waldenstrom macroglobulinemia represents a lymphoplasmacytic lymphoma with an indolent Clinical course. The existing literature associates this hematologic malignancy with various autoimmune disorders. Notwithstanding, these autoinnmune conditions have not been comprehensively characterized or systematized to date. As a result, their clinical implications remain largely unknown. The authors offer a comprehensive review of the existing literature on various hematologic and nonhematologic autoimmune disorders documented in the course of Waldenstrom macroglobulinemia. Whereas some of them are thought to be secondary to a dysfunctional immune response associated with an underlying malignant process, others Might be primary and might even play a role in its pathogenesis. Moreover, the observations that personal history and family history of certain autoimmune diseases were associated with an increased risk of subsequent Waldenstrom macroglobulinemia strengthen further the hypothesis that shared susceptibility genes and chronic antigenic stimulation might predispose individuals to both conditions. (C) 2014 Elsevier Inc. All rights reserved.