A novel dizinc bridged hydroxamate model for hydroxamate inhibited zinc hydrolases

被引：23

作者：

Brown, DA ^{[1
]}

Errington, W

Fitzpatrick, NJ

Glass, WK

Kemp, TJ

Nimir, H

Ryan, AT

机构：

[1] Univ Coll Dublin, Dept Chem, Dublin 4, Ireland

[2] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 11期

关键词：

D O I：

10.1039/b202612k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of Zn(OAc)(2).2H(2)O with tmen leads to the formation of [Zn(tmen)(OAc)(2)] (I) which reacts with benzohydroxamic acid to form Zn(BA)(2).H2O (II) and the novel dizinc hydroxamate bridged complex [Zn-2(mu-OAc)(2)(OAc)(2)-(mu-BA)(tmen)](III), which may also be prepared by self-assembly and whose structure closely mimics that of the native hydroxamate inhibited Aeromonas proteolytica aminopeptidase.

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收藏

页码：1210 / 1211

页数：2

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