Does the Adult Human Ciliary Body Epithelium Contain "True" Retinal Stem Cells?

被引：24

作者：

Froen, Rebecca ^{[1
]}

Johnsen, Erik O. ^{[1
]}

Nicolaissen, Bjorn ^{[1
]}

Facsko, Andrea ^{[2
]}

Petrovski, Goran ^{[2
,3
,4
]}

Moe, Morten C. ^{[1
]}

机构：

[1] Oslo Univ Hosp, Dept Ophthalmol, N-0407 Oslo, Norway

[2] Univ Szeged, Dept Ophthalmol, Fac Med, H-6720 Szeged, Hungary

[3] Univ Debrecen, Stem Cells & Eye Res Lab, Dept Biochem & Mol Biol, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary

[4] Univ Debrecen, Apoptosis & Genom Res Grp, Hungarian Acad Sci, H-4032 Debrecen, Hungary

来源：

BIOMED RESEARCH INTERNATIONAL | 2013年 / 2013卷

关键词：

NEURAL PROGENITOR CELLS; STEM/PROGENITOR CELLS; HUMAN EYES; DIFFERENTIATION; IDENTIFICATION; REGENERATION; GENERATION; CULTURE; MOUSE; IRIS;

D O I：

10.1155/2013/531579

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recent reports of retinal stem cells being present in several locations of the adult eye have sparked great hopes that they may be used to treat the millions of people worldwide who suffer from blindness as a result of retinal disease or injury. A population of proliferative cells derived from the ciliary body epithelium (CE) has been considered one of the prime stem cell candidates, and as such they have received much attention in recent years. However, the true nature of these cells in the adult human eye has still not been fully elucidated, and the stem cell claim has become increasingly controversial in light of new and conflicting reports. In this paper, we will try to answer the question of whether the available evidence is strong enough for the research community to conclude that the adult human CE indeed harbors stem cells.

引用

页数：7

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