Quantification of Nitroimidazoles Residues in Swine Liver by Liquid Chromatography-Mass Spectrometry with Atmospheric Pressure Chemical Ionization

被引：7
|
作者：
Wang, Hai [1 ,2 ]
Wang, Zijian [2 ]
Liu, SuYing [1 ]
Jiang, Yanbing [1 ]
Wu, Yinliang [1 ]
Shan, Jihao [1 ]
机构：
[1] China Anim Dis Control Ctr, Minist Agr, Qual Control & Inspect Ctr Anim Prod, Beijing 100026, Peoples R China
[2] Chinese Acad Sci, Ecoenvironm Sci Res Ctr, State Key Lab Environm Aquat Chem, Beijing 100085, Peoples R China
来源：
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2009年 / 82卷 / 04期
关键词：
Nitroimidazoles; LC-APCI-MS; Swine liver;
D O I：
10.1007/s00128-008-9591-6
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
A liquid chromatography-mass spectrometry method was developed for the simultaneous determination of ronidazole (RNZ), metronidazole (MNZ) and dimetridazole (DMZ) residues in swine liver. Following liquid-liquid extraction, the HLB solid-phase extraction was used for further purification. The targets were detected by atmospheric pressure chemical ionization (APCI) following the reverse phase liquid chromatography separation. Consequently, the detection limits for the method were 0.5 mu g/kg for MNZ, 1.0 mu g/kg for RNZ and 0.5 mu g/kg for DMZ, respectively. The accuracies were determined using swine liver samples fortified at levels of 0.5, 1, 2, and 4 mu g/kg and the mean recoveries of the analytes were between 66% and 81%.
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页码：411 / 414
页数：4
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