Microbial tryptophan catabolites in health and disease

被引：1464

作者：

Roager, Henrik M. ^{[1
,2
]}

Licht, Tine R. ^{[2
]}

机构：

[1] Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, DK-1958 Frederiksberg, Denmark

[2] Tech Univ Denmark, Natl Food Inst, DK-2800 Lyngby, Denmark

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

ARYL-HYDROCARBON RECEPTOR; HUMAN GUT MICROBIOME; AROMATIC-AMINO-ACIDS; INDOLE-3-PROPIONIC ACID; INDOXYL SULFATE; BACTERIAL METABOLITES; INTESTINAL MICROBIOTA; LIPID-PEROXIDATION; INDOLEACETIC-ACID; POTASSIUM BROMATE;

D O I：

10.1038/s41467-018-05470-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Accumulating evidence implicates metabolites produced by gut microbes as crucial mediators of diet-induced host-microbial cross-talk. Here, we review emerging data suggesting that microbial tryptophan catabolites resulting from proteolysis are influencing host health. These metabolites are suggested to activate the immune system through binding to the aryl hydrocarbon receptor (AHR), enhance the intestinal epithelial barrier, stimulate gastrointestinal motility, as well as secretion of gut hormones, exert anti-inflammatory, antioxidative or toxic effects in systemic circulation, and putatively modulate gut microbial composition. Tryptophan catabolites thus affect various physiological processes and may contribute to intestinal and systemic homeostasis in health and disease.

引用

页数：10

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