Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers
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Miyata, Yasuyoshi
[1
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Mukae, Yuta
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Nagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, JapanNagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, Japan
Mukae, Yuta
[1
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Harada, Junki
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Nagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, JapanNagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, Japan
Harada, Junki
[1
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Matsuda, Tsuyoshi
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Nagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, JapanNagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, Japan
Matsuda, Tsuyoshi
[1
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Mitsunari, Kensuke
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Nagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, JapanNagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, Japan
Mitsunari, Kensuke
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Matsuo, Tomohiro
[1
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Ohba, Kojiro
[1
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Sakai, Hideki
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Nagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, JapanNagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, Japan
Sakai, Hideki
[1
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[1] Nagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, Japan
Oxidative stress plays an important role in cellular processes. Consequently, oxidative stress also affects etiology, progression, and response to therapeutics in various pathological conditions including malignant tumors. Oxidative stress and associated outcomes are often brought about by excessive generation of reactive oxygen species (ROS). Accumulation of ROS occurs due to dysregulation of homeostasis in an otherwise strictly controlled physiological condition. In fact, intracellular ROS levels are closely associated with the pathological status and outcome of numerous diseases. Notably, mitochondria are recognized as the critical regulator and primary source of ROS. Damage to mitochondria increases mitochondrial ROS (mROS) production, which leads to an increased level of total intracellular ROS. However, intracellular ROS level may not always reflect mROS levels, as ROS is not only produced by mitochondria but also by other organelles such as endoplasmic reticulum and peroxisomes. Thus, an evaluation of mROS would help us to recognize the biological and pathological characteristics and predictive markers of malignant tumors and develop efficient treatment strategies. In this review, we describe the pathological significance of mROS in malignant neoplasms. In particular, we show the association of mROS-related signaling in the molecular mechanisms of chemically synthesized and natural chemotherapeutic agents and photodynamic therapy.
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Univ Fed Rio de Janeiro, Inst Quim, Dept Quim Organ, Lab Fotoquim, BR-21949900 Rio De Janeiro, BrazilUniv Fed Rio de Janeiro, Inst Quim, Dept Quim Organ, Lab Fotoquim, BR-21949900 Rio De Janeiro, Brazil
de Souza, Pierre Andre
Rodrigues, Clara
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Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Biol Celular & Parasitol, BR-21949900 Rio De Janeiro, BrazilUniv Fed Rio de Janeiro, Inst Quim, Dept Quim Organ, Lab Fotoquim, BR-21949900 Rio De Janeiro, Brazil
Rodrigues, Clara
Santiago, Ana Paula S. A.
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Univ Fed Rio de Janeiro, Inst Bioquim Med, Programa Biofis & Bioquim Celular, BR-21949900 Rio De Janeiro, Brazil
Univ Fed Rio de Janeiro, Programa Biol Mol Biotecnol, BR-21941 Rio De Janeiro, BrazilUniv Fed Rio de Janeiro, Inst Quim, Dept Quim Organ, Lab Fotoquim, BR-21949900 Rio De Janeiro, Brazil
Santiago, Ana Paula S. A.
de Lucas, Nanci Camara
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Univ Fed Rio de Janeiro, Inst Quim, Dept Quim Organ, Lab Fotoquim, BR-21949900 Rio De Janeiro, BrazilUniv Fed Rio de Janeiro, Inst Quim, Dept Quim Organ, Lab Fotoquim, BR-21949900 Rio De Janeiro, Brazil
de Lucas, Nanci Camara
Leitao, Gilda Guimaraes
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Univ Fed Rio de Janeiro, Nucleo Pesquisa Prod Naturais, BR-21949900 Rio De Janeiro, BrazilUniv Fed Rio de Janeiro, Inst Quim, Dept Quim Organ, Lab Fotoquim, BR-21949900 Rio De Janeiro, Brazil
Leitao, Gilda Guimaraes
Galina Filho, Antonio
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Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Programa Biol Celular & Parasitol, BR-21949900 Rio De Janeiro, BrazilUniv Fed Rio de Janeiro, Inst Quim, Dept Quim Organ, Lab Fotoquim, BR-21949900 Rio De Janeiro, Brazil
Galina Filho, Antonio
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY,
2011,
21
(03):
: 420
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426