Pathological and Pharmacological Roles of Mitochondrial Reactive Oxygen Species in Malignant Neoplasms: Therapies Involving Chemical Compounds, Natural Products, and Photosensitizers

被引:11
|
作者
Miyata, Yasuyoshi [1 ]
Mukae, Yuta [1 ]
Harada, Junki [1 ]
Matsuda, Tsuyoshi [1 ]
Mitsunari, Kensuke [1 ]
Matsuo, Tomohiro [1 ]
Ohba, Kojiro [1 ]
Sakai, Hideki [1 ]
机构
[1] Nagasaki Univ, Dept Urol, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, Japan
来源
MOLECULES | 2020年 / 25卷 / 22期
关键词
oxidative stress; mitochondrial reactive oxygen species; chemical compounds; natural product; photodynamic therapy; malignancies; TRAIL-INDUCED APOPTOSIS; CELL-CYCLE ARREST; SODIUM-FLUORIDE; CANCER-CELLS; NEOADJUVANT CHEMOTHERAPY; 5-AMINOLEVULINIC ACID; UNCOUPLING PROTEIN-2; PHOTODYNAMIC THERAPY; DOWN-REGULATION; CYTOCHROME-C;
D O I
10.3390/molecules25225252
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oxidative stress plays an important role in cellular processes. Consequently, oxidative stress also affects etiology, progression, and response to therapeutics in various pathological conditions including malignant tumors. Oxidative stress and associated outcomes are often brought about by excessive generation of reactive oxygen species (ROS). Accumulation of ROS occurs due to dysregulation of homeostasis in an otherwise strictly controlled physiological condition. In fact, intracellular ROS levels are closely associated with the pathological status and outcome of numerous diseases. Notably, mitochondria are recognized as the critical regulator and primary source of ROS. Damage to mitochondria increases mitochondrial ROS (mROS) production, which leads to an increased level of total intracellular ROS. However, intracellular ROS level may not always reflect mROS levels, as ROS is not only produced by mitochondria but also by other organelles such as endoplasmic reticulum and peroxisomes. Thus, an evaluation of mROS would help us to recognize the biological and pathological characteristics and predictive markers of malignant tumors and develop efficient treatment strategies. In this review, we describe the pathological significance of mROS in malignant neoplasms. In particular, we show the association of mROS-related signaling in the molecular mechanisms of chemically synthesized and natural chemotherapeutic agents and photodynamic therapy.
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页数:21
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