Preparation of tri- and difluoromethylated amines from aldimines using (trifluoromethyl) trimethylsilane

被引：57

作者：

Prakash, G. K. Surya ^{[1
]}

Mogi, Ryo

Olah, George A.

机构：

[1] Univ So Calif, Loker Hydrocarbon Res Inst, Los Angeles, CA 90089 USA

[2] Univ So Calif, Dept Chem, Los Angeles, CA 90089 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 16期

关键词：

D O I：

10.1021/ol061357w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Addition of a trifluoromethyl group into aldimines was accomplished using ( trifluoromethyl) trimethylsilane with tetraalkylammonium fluorides as initiators, and the resulting adducts were converted to difluoromethylated imines in the presence of excess fluoride. The imines were reduced to difluoromethylated amines using sodium borohydride.

引用

页码：3589 / 3592

页数：4

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