Effect of hormone replacement therapy on blood serum lipids in postmenopausal women with type 2 diabetes

被引：0

作者：

Kozlov, SG ^{[1
]}

Dotsenko, YV ^{[1
]}

Sankova, AV ^{[1
]}

Lyakishev, AA ^{[1
]}

Tvorogova, MG ^{[1
]}

Afanasieva, OI ^{[1
]}

Titov, VN ^{[1
]}

Pokrovsky, SN ^{[1
]}

Naumov, VG ^{[1
]}

机构：

[1] AL Myasnikov Cardiol Inst, Moscow 121552, Russia

来源：

KARDIOLOGIYA | 2002年 / 42卷 / 07期

关键词：

hormone replacement therapy; estrogens; postmenopause; diabetes; type; 2; lipids;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are limited data concerning influence of hormone replacement therapy (HRT) on lipid profile in women with type 2 diabetes. Aim of the study was to compare changes of blood lipids during HRT in postmenopausal women with and without type 2 diabetes. Seventy seven women included in the study were assigned to I of 4 groups, basing on being diabetic or nondiabetic, and further subdivided into users of estrogen alone (ERT), and of estrogen plus progestin (EPRT). Effect of 6-month ERT (oral estradiol valerate 2 mg/day) and EPRT (oral estradiol valerate 2 mg/day sequentially combined with cyproterone acetate 1 mg/day) on total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and lipoprotein (a) [Lp(a)] was separately assessed. EPRT and ERT caused decrease in LDL-C by 15% and 12%, and increase in HDL-C by 12% and 13%, respectively, in patients with diabetes (p < 0.05 in all cases). LDL-C decreased by 11% and 15%, respectively, in women without diabetes (p < 0.05 in all cases). Lp(a) was also reduced 25% with EPRT (p< 0.01) and ERT (p< 0.05). HDL-C increased 10% (p<0.05) with ERT but remained unchanged with EPRT. In conclusion, changes in all lipid parameters except Lp(a) caused by ERT and EPRT were comparable in postmenopausal women with and without type 2 diabetes.

引用

页码：47 / 52

页数：6

共 23 条

[1]

Afanas'eva O.I., 1995, B EKSP BIOL MED, V10, P398

[2]

Amer Diabet Assoc, 2000, DIABETES CARE, V23, pS32

[3] Estrogen replacement therapy decreases hyperandrogenicity and improves glucose homeostasis and plasma lipids in postmenopausal women with noninsulin-dependent diabetes mellitus [J].